Enteroendocrine cell reprogramming in metabolic disease
Funded at Tufts University Boston · NIH-11365664 · Data updated 2026-11-12
A study exploring how gut hormone–producing cells can be reprogrammed to improve long-term weight management in obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 21, 2026 |
| Project end | February 28, 2030 |
| Funding year | 2026 |
| Award (this year) | $735,358 |
| NIH project number | 1R01DK139007-01A1 |
| Project ID | NIH-11365664 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with obesity or metabolic syndrome who may benefit from better long-term weight management.
✕Less likely to help
Individuals without obesity-related metabolic issues may not directly benefit.
What this research studies
We will study gut enteroendocrine cells (EECs) and how their function affects GLP-1 levels and weight in obesity. Using a novel EEC reporter mouse and gut organoids, researchers will map the EEC gene activity and how these cells behave at the single-cell level. Early data suggests immune cells and mitochondria influence EEC function, which could be targeted for safer, longer-lasting weight control.
Why it matters
Potential benefit: If successful, this work could lead to new ways to sustain weight loss by improving gut hormone balance.
How similar studies have gone: Other studies show gut hormones and EECs influence weight, but this approach is exploring a novel reprogramming angle.
Where this research is happening
-
Tufts University Boston
Boston, United States Active
Researchers
- Principal investigator: Lee, Jennifer — Tufts University Boston
- Study coordinator: Lee, Jennifer
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.