Network for studying rare and atypical diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

RADIANT is a collaborative network involving 14 clinical sites and laboratories focused on identifying and understanding atypical forms of diabetes. The study aims to enroll individuals and families with undiagnosed rare diabetes, investigate the underlying mechanisms, and perform genetic screening and deeper phenotyping. Participants will undergo a series of assessments, including questionnaires, blood tests, and whole genome sequencing, to uncover novel forms of diabetes and their etiologies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

The following criteria or phenotypes will be considered for suspecting "atypical" participants:

* Type 2 diabetes diagnosed at a time when the individual was prepubertal or non-obese
* Mendelian pattern, especially with early onset (\<18 years old)
* Syndromic (multiple systems involved)
* Lipodystrophic
* Extremes of BMI
* "Mitochondrial" characteristics (e.g., myopathy, hearing deficits)
* Non-progressive
* Rapidly progressive ("fulminant")
* Low insulin requirements (\<0.5 u/kg/day)
* Cyclical hyperglycemia with periods of remission
* Lean persons with polycystic ovarian syndrome (PCOS)
* History of gestational diabetes (GDM) when lean
* Lean insulin-resistant persons
* If islet autoantibodies and beta-cell function parameters have been measured (where "A" = islet cell autoantibodies, "B" = beta-cell function):

oA-B- (i.e., lacking islet autoimmunity makers and lacking beta cell function) oA-B+ with unprovoked DKA at initial presentation (i.e., lacking islet autoimmune markers, with preserved beta-cell function, but presenting with unprovoked DKA) oA-B+ of very young onset (pre-pubertal) (i.e., lacking islet autoimmune markers, with preserved beta-cell function, but very early onset T2D-like phenotype)

Exclusion Criteria:

* Those with high likelihood of typical type 1, typical type 2, known monogenic, or other known secondary forms of diabetes
* Refusal of consent for genetic testing
* Islet autoantibody positive (participants who are islet autoantibody positive but present with additional atypical features i.e. syndromic, strong linear family history of diabetes may not be excluded)
* Women who are currently pregnant

Where it's running

• University of Colorado- Denver
  Aurora, Colorado, United States Recruiting
• University of Chicago
  Chicago, Illinois, United States Recruiting
• Indiana University
  Indianapolis, Indiana, United States Recruiting
• University of Maryland
  Baltimore, Maryland, United States Recruiting
• Massachusetts General Hospital (MGH)
  Boston, Massachusetts, United States Recruiting
• University of Michigan
  Ann Arbor, Michigan, United States Recruiting

Study contacts

• Study coordinator: Jeffrey Krischer, PhD
• Email: contact@atypicaldiabetesnetwork.org
• Phone: 813-396-9501

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Using the 'Support' online training and peer program for adults with type 1 diabetes

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.