Effects of Lipids on Health in Night Shift Workers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how circulating and tissue-specific lipids affect vascular function and insulin sensitivity in individuals who work night shifts. It aims to understand the mechanisms by which circadian misalignment contributes to increased risks of cardiovascular disease and Type 2 diabetes. Participants will undergo a time-restricted eating intervention to assess its impact on lipid levels, blood pressure, and glucose homeostasis. The study targets a significant portion of the workforce that experiences chronic circadian misalignment due to night shifts.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18-65 years old
* worked the night shift for the last 1 year or more,
* habitually sleep 5-9 hours per 24h period (night shift workers typically experience chronic insufficient sleep),
* body mass index (BMI) of 20.0 - 35.0 kg/m2 and weight stable (plus or minus 5% of current body weight in the last 6 months); sedentary to mild physical activity level (less than 2 days of planned exercise per week);

Exclusion Criteria:

* existing diagnosed sleep or eating disorder (e.g. obstructive sleep apnea \[OSA\], periodic limb movements of sleep \[PLMS\], narcolepsy, travel more than 1 time zone in 3 weeks before the study; anorexia nervosa, more than one food allergy to maintain flexibility in diet planning);
* following any TRE (time-restricted eating) or intermittent fasting plan in the last year;
* following any special diet plan, like paleo, keto, gluten-free or vegan, that can affect the primary lipid outcome measures in the last 6 months; any clinically significant surgical condition within the last year;
* diagnosed diabetes or cardiovascular disease

  * The prevalence of insomnia in shift workers is fairly high, ranging from 12.8% to 76.4%, which is higher than estimated for the general population. Insomnia itself is associated with elevated neural cardiovascular responsiveness to stress compared to people without insomnia. Thus, since excessive sleepiness and symptoms of insomnia may be present in night shift workers they will not be exclusionary.

Where it's running

• Colorado State University
  Fort Collins, Colorado, United States Recruiting

Study contacts

• Principal investigator: Josiane L Broussard, PhD — Colorado State University
• Study coordinator: Josiane L Broussard, PhD
• Email: josiane.broussard@colostate.edu
• Phone: 9704913103

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.