Identifying genes that affect metabolic diseases and insulin resistance
Official title: Credentialing metabolic disease genes through human genetics and functional genomics
Funded at VA San Diego Healthcare System · NIH-11063124 · Data updated 2026-11-12
This study is looking at how our genes might affect insulin resistance, which can lead to type 2 diabetes, and it's especially focused on helping veterans and people of African descent by finding new treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| NIH project number | 5I01BX006293-02 |
| Project ID | NIH-11063124 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include veterans, especially those of African ancestry, who are experiencing insulin resistance or related metabolic conditions.
✕Less likely to help
Patients who do not have insulin resistance or related metabolic diseases may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to insulin resistance, a key driver of type 2 diabetes and other serious health conditions. By using advanced genomic techniques, the study aims to identify specific genes that can be targeted for new treatments, particularly focusing on populations that have been underrepresented in previous research, such as individuals of African descent. The approach combines genetic analysis with functional studies to validate potential therapeutic targets, which could lead to more effective treatments for obesity-related metabolic diseases. The research is particularly relevant for veterans, who are disproportionately affected by these conditions.
Why it matters
Potential benefit: If successful, this research could lead to new, more effective treatments for insulin resistance and related metabolic diseases, improving health outcomes for many patients.
How similar studies have gone: Previous research has shown promise in identifying genetic factors related to metabolic diseases, but this study aims to address gaps in representation and understanding, making it a novel approach.
Where this research is happening
-
VA San Diego Healthcare System
San Diego, United States Active
Researchers
- Principal investigator: Majithia, Amit — VA San Diego Healthcare System
- Study coordinator: Majithia, Amit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.