Impact of Metabolic Abnormalities and Lifestyle on Heart Failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess how metabolic abnormalities, lifestyle behaviors, and dietary patterns affect the prognosis of heart failure in patients. It plans to enroll 1,500 participants aged 14 years and older who have heart failure with reduced or mid-range ejection fraction. Participants will be followed for five years, during which data on their metabolic health, lifestyle choices, and diet will be collected through standardized questionnaires. The study will also track major adverse cardiac events through medical records and discharge lists.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. aged 14 years or older;
2. typical symptoms of heart failure according to the Framingham criteria;
3. left ventricular ejection fraction (LVEF) \<50%, demonstrated by echocardiography or cardiac magnetic resonance, which include either patients with mid-range EF (HFmEF) or with reduced EF (HFrEF) with relevant structural and functional cardiac changes and/or elevated N-terminal pro-brain B-type natriuretic peptide (pro-BNP) (e.g., ≥400 pg/mL).

Exclusion Criteria:

1. age \<14 years or ≥90 years;
2. pregnancy;
3. cancer with a life expectancy of less than one year;
4. participation in other trials;
5. endocarditis, pericardial diseases, or congenital heart diseases;
6. heart failure secondary to non-cardiac diseases (e.g., pulmonary heart disease, infection, infiltration, metabolic derangements, severe anemia, sepsis, and arteriovenous fistula);
7. lack of informed consent;
8. refusal of the drug treatment or intervention recommended by the guidelines.

Where it's running

• Ruijin Hospital, Shanghai Jiaotong University School of Medicine
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Principal investigator: Zhijun Wu, MD — Ruijin Hospital
• Study coordinator: Zhijun Wu, MD
• Email: totito19822005@126.com
• Phone: 008613818908053

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• NT-proBNP–guided heart failure screening for people 65+ in rural China

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• Voice-based detection of heart failure deterioration using Noah Labs Vox

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.