Understanding how Foxc2 affects metabolic diseases
Official title: Novel role of Foxc2 in regulating metabolic disease
Funded at Boston Children's Hospital · NIH-10990522 · Data updated 2026-11-12
This study is looking at a protein called Foxc2 to see how it affects the lymphatic system, which helps with fluid balance and immune health, and it could help find new ways to treat heart and weight-related issues like obesity and atherosclerosis.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $125,658 |
| NIH project number | 5K99HL171947-02 |
| Project ID | NIH-10990522 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 who are experiencing metabolic or cardiovascular disorders.
✕Less likely to help
Patients with metabolic or cardiovascular conditions unrelated to lymphatic function may not benefit from this research.
What this research studies
This research investigates the role of a protein called Foxc2 in the lymphatic system, which is crucial for fluid balance, immune function, and fat absorption. By studying how Foxc2 influences lymphatic function in both healthy and diseased states, the research aims to uncover new therapeutic targets for treating cardiovascular and metabolic disorders like obesity and atherosclerosis. The approach includes using advanced animal models to observe the effects of manipulating Foxc2 levels in lymphatic cells. This could lead to a better understanding of how lymphatic dysfunction contributes to these diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for metabolic and cardiovascular diseases, improving health outcomes for patients.
How similar studies have gone: While the specific role of Foxc2 in adult lymphatic function is not well-studied, similar research has shown promise in understanding lymphatic contributions to metabolic diseases.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Cui, Kui — Boston Children's Hospital
- Study coordinator: Cui, Kui
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.