Examining biomarkers in osteoarthritic thumb joints

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to analyze molecular markers in synovial fluid, bone, and articular cartilage from patients with osteoarthritis of the thumb basal joint. It will evaluate the degradation of extracellular matrix proteins in relation to the patient's metabolic profile and compare these findings with similar degradation profiles in knee joints affected by osteoarthritis. Patients scheduled for trapeziectomy will have synovial fluid aspirated and various assessments conducted, including grip strength and pain levels, both preoperatively and one year post-surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women age ≥ 25 years
* Radiologically confirmed and symptomatic thumb basal joint osteoarthritis (OA) planned for trapeziectomy

Exclusion Criteria:

* Previous surgery to the affected thumb basal joint
* Post-traumatic thumb basal joint OA
* Rheumatoid arthritis or other chronic inflammatory arthritis, history of psoriasis affecting joints, gout or pseudogout
* Ongoing infection in the hand or wrist
* Inability to co-operate with the follow-up protocol or to assimilate information about the study protocol (language difficulties, severe psychiatric disorder, cognitive impairment, drug addiction)
* Systemic or intra-articular glucocorticoids or intraarticular platelet-rich plasma or hyaluronic acid injections in the affected joint within 3 months prior to enrollment

Where it's running

• Aleris Specialistläkare Hyllie
  Malmö, Skåne County, Sweden Recruiting
• Department of Hand Surgery, Skane University Hospital
  Malmö, Skåne County, Sweden Not yet recruiting

Study contacts

• Principal investigator: Elisabeth Brogren, MD, PhD — Department of hand surgery, Region Skåne
• Study coordinator: Elisabeth Brogren, MD, PhD
• Email: elisabeth.brogren@med.lu.se
• Phone: +46 40331723

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.