Identifying mortality risk in patients with metabolic diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to establish a mortality risk profile for patients with metabolic diseases by analyzing clinical and biological parameters. It focuses on a hospital cohort, utilizing high throughput screening of biological samples to assess metabolomics, genetics, transcriptomics, and epigenomics. The study will collect follow-up data from the National System of Health Data to track hospitalizations and medical consultations. By identifying clinico-biological determinants, the study seeks to improve prediction models for mortality and complications associated with metabolic disorders.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diabetic: antecedent - treatment - or glycemia\> = 1.26 g / dl - or HbA1C\> = 6.5% and or
* Obese: BMI\> = 30 and or
* Metabolic syndrome defined AND
* Patient having given written consent to participate in the study or collection of the consent of the witness
* Social insured patient (excluding AME)
* Patient willing to comply with all procedures of the study and its duration AND

Patient also presenting a pathology among:

* Cardiology:

  * Coronary patient(history of myocardial infarction, coronary bypass, or coronary angioplasty or stenosis greater than 50% on an epicardial vessel documented on coronary angiography)
  * Patient with systolic or diastolic heart failure
  * Patient with atrial fibrillation
  * Patient with aortic stenosis (Vmax\> 2.5 m / s)
  * Patient with high blood pressure
* neurology:

  * ischemic stroke
  * intracerebral hemorrhage
  * transient ischemic attack
* diabetology:

  * Obesity without diabetes
  * Diabetes T2
  * T1 diabetes
  * Monogenic Diabetes / MODY
  * African Diabetes
  * Diabetes secondary to pancreatopathy / liver cirrhosis
  * Diabetes post transplantation / post immunotherapy
  * Diabetes associated with Steinert's disease
* hepatology: hepatological pathology
* nephrology: nephrology

Exclusion Criteria:

* Unscheduled hospitalization less than 3 months old
* Ongoing treatment :

  * Cytotoxic chemotherapy
  * Radiotherapy
* HIV and / or HCV and / or active HBV infection
* OMS score\> = 2
* Pregnant woman

Where it's running

• Ch Boulogne-Sur-Mer
  Boulogne-sur-Mer, France Recruiting
• Hop Cardiologique Chr Lille
  Lille, France Recruiting
• Hop Claude Huriez Chr Lille
  Lille, France Recruiting

Study contacts

• Principal investigator: François Pattou, MD,PhD — University Hospital, Lille
• Study coordinator: François Pattou, MD,PhD
• Email: francois.pattou@chru-lille.fr
• Phone: 03 20 44 42 73

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.