Investigating the role of a protein in liver disease and metabolic disorders
Role of SUN1 in MASLD and metabolic disease
This study is looking at how a protein called SUN1 might affect liver health in people with metabolic dysfunction-associated steatotic liver disease (MASLD), and we're inviting patients to help by sharing genetic samples to see how different versions of this protein could play a role in this condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11057704 on NIH RePORTER |
What this research studies
This research focuses on metabolic dysfunction-associated steatotic liver disease (MASLD), a common chronic liver condition that can lead to serious health issues. The study examines the role of a specific protein, SUN1, which is believed to influence liver health and metabolic processes. By analyzing genetic variants of SUN1, researchers aim to understand how these variants may contribute to the development of MASLD and related metabolic disorders. Patients may be involved in providing genetic samples to help identify the impact of SUN1 on liver disease.
Who could benefit from this research
Good fit: Ideal candidates for participation include adults over 21 years old who are at risk for or diagnosed with metabolic dysfunction-associated steatotic liver disease.
Not a fit: Patients with liver disease caused by factors other than metabolic dysfunction, such as viral hepatitis or alcohol-related liver disease, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating MASLD and related metabolic diseases.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors contributing to liver diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Brady, Graham F. — University of Michigan at Ann Arbor
- Study coordinator: Brady, Graham F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.