Condition

Weight Loss clinical trials and research

• 53Clinical trials
• 154NIH research projects
• 1New in 30 days
• 15Countries

Newest Weight Loss clinical trials

All recruiting trials (53)

• 15-year outcomes after sleeve gastrectomy in France

  This study looks at how people who had sleeve gastrectomy have fared over 15 years to see long-term weight changes and health effects.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07883018

• Do GLP-1 medicines affect breastmilk production and milk quality after pregnancy

  This study will test whether weight loss from injected GLP-1 receptor agonists changes how much milk moms produce or the nutritional makeup of their breast milk.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT07720414

• Personalized 26-week program to help keep weight off

  This 26-week program tests whether tailored messages, weekly check-ins and weighing, and optional health coaching help adults who recently lost at least 7% of their weight keep it off.

  Recruiting University of Utah · Salt Lake City, Utah · NCT07577765

• HRS9531 PK in adults with different liver function

  This Phase 1 study tests how HRS9531 behaves in the body and whether it is safe in people with mild, moderate liver impairment and those with normal liver function.

  Recruiting Phase 1 Fujian Shengdi Pharmaceutical Co., Ltd. · Zhengzhou, Henan · NCT07540754

• Fasted versus fed aerobic exercise for weight loss and heart health

  This 16-week program will see if doing aerobic exercise before breakfast (fasted) versus after eating helps adults with overweight or obesity lose more weight and improve heart-related measures.

  Recruiting Phase 2 Arkansas Colleges of Health Education · Fort Smith, Arkansas · NCT07487090

• Multi-strain Bacillus probiotic for cesarean-delivered newborns

  This study tests whether daily multi-strain Bacillus spore probiotics help cesarean-born newborns grow better and have fewer tummy troubles by supporting a healthier gut microbiota.

  Recruiting Anabio R&D · Hanoi · NCT07320287

• OverStitch NXT Endoscopic Suture System for Endoscopic Sleeve Gastrectomy in Obesity

  This trial tests whether the OverStitch NXT endoscopic suture system, used with lifestyle management, helps people with obesity lose weight compared to lifestyle management alone.

  Recruiting Boston Scientific Corporation · Beijing, China/Beijing · NCT07276815

• Does giving IV fluids to mothers before birth change how much a newborn loses weight in the first days?

  This project sees if the amount of IV fluids a mother receives before delivery affects weight loss in formula-fed newborns during their first two days of life.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens, Picardie · NCT07243054

• How GLP‑1 weight‑loss medicines affect taste and eating habits

  This project sees if adults with obesity who take GLP‑1 drugs for at least 12 weeks notice changes in taste, food preferences, and eating habits.

  Recruiting at 3 sites San Raffaele Telematic University · Roma, Italy and 3 other locations · NCT07229170

• Personalized weight-loss medication plan for adults with bipolar disorder

  This pilot tests whether matching FDA-approved weight-loss medicines to specific obesity types helps adults aged 18–65 with bipolar disorder lose weight.

  Recruiting Phase 4 Mayo Clinic · Rochester, Minnesota · NCT07213466

• Orbera365 Intragastric Balloon System for Weight Loss

  This trial tests whether placing the Orbera365 balloon plus lifestyle support helps adults with obesity lose weight compared to lifestyle support alone.

  Recruiting Boston Scientific Corporation · Shanghai, Shanghai Municipality · NCT07195708

• Time-restricted eating to help keep weight off

  This 12-month randomized test will see if eating only within a 10-hour daily window helps adults who recently lost weight keep it off and limit fat regain.

  Recruiting NYU Langone Health · New York, New York · NCT07190170

• Daily postbiotic gummy plus nutrition advice for adults with overweight or obesity

  This project will test whether taking a daily postbiotic gummy together with nutritional advice helps adults with overweight or obesity improve body composition, glucose metabolism, and gut microbiota.

  Recruiting Clinica Universidad de Navarra, Universidad de Navarra · Pamplona, Navarre · NCT07165431

• Efsubaglutide alfa for weight loss after metabolic surgery

  This trial will test whether efsubaglutide alfa helps people who remain obese six months after metabolic surgery lose weight and improve obesity-related health problems.

  Recruiting Phase 4 The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT07163650

• Family COMIDA — helping Hispanic families choose healthier foods to prevent and reduce obesity

  This program tests family-centered support (parent counseling, weekly phone coaching, monthly group sessions, and child education) to help Hispanic parents/caregivers and their 8–12-year-old children prevent or reduce obesity.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York · NCT07144800

• Implant-based breast reconstruction after bariatric (weight-loss) surgery

  This registry-based project will use national data to see how common breast implants are and whether women who've had bariatric weight-loss surgery have different complication rates after implant-based breast augmentation or reconstruction.

  Recruiting Vastra Gotaland Region · Gothenburg · NCT07059104

• Transoral outlet reduction plus lifestyle program for weight regain after gastric bypass

  This trial will test whether adding a transoral outlet reduction procedure to an intensive lifestyle program helps people who regained weight after Roux-en-Y gastric bypass lose more weight than lifestyle changes alone.

  Recruiting at 9 sites Boston Scientific Corporation · Irvine, California and 11 other locations · NCT07015424

• Megestrol acetate to prevent weight loss during preoperative chemotherapy for locally advanced colorectal cancer

  This trial tests whether taking megestrol acetate during mFOLFOX6 neoadjuvant chemotherapy can prevent weight loss and improve appetite in adults with locally advanced colorectal cancer.

  Recruiting Phase 3 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT06998758

• Protein supplements with semaglutide and a calorie-restricted diet for weight loss

  This will test whether adding daily protein supplements to semaglutide plus a calorie-restricted diet helps adults with overweight or obesity lose more weight, preserve muscle, and reduce weight regain.

  Recruiting Chinese Academy of Sciences · Hangzhou, Zhejiang · NCT06989203

• Probiotic or semaglutide plus diet to reduce body weight

  This project will test whether adding a probiotic (Lactobacillus paracasei LC-19) or semaglutide to a calorie-restricted diet helps overweight adults lose weight and improve blood sugar and lipid levels.

  Recruiting Chinese Academy of Sciences · Hangzhou, Zhejiang · NCT06989177

• Analyzing bacterial overgrowth in pancreatic cancer patients

  This study is testing how common bacterial overgrowth is in pancreatic cancer patients who are losing weight and seeing if it relates to their surgery status.

  Recruiting Cedars-Sinai Medical Center · Los Angeles, California · NCT06988150

• Reducing heart disease risk in 12–15-year-olds with severe obesity

  This will try semaglutide in 12–15-year-olds with class 2–3 obesity to see if it changes weight, heart-related risk markers, body composition, and fitness over about a year.

  Recruiting University of Kentucky · Lexington, Kentucky · NCT06967389

• Impact of Peanut Consumption on Health During Weight Loss in Older Adults

  This study is testing if eating peanuts every day can help older adults who are trying to lose weight improve their bone health and overall well-being compared to those who don’t eat peanuts.

  Recruiting Rutgers, The State University of New Jersey · New Brunswick, New Jersey · NCT06949280

• How weight-loss surgery and vagal nerve stimulation affect thinking and the brain

  We will test whether weight-loss surgery and a 30-day at-home vagal nerve stimulation (tVNS) treatment improve thinking and brain function in adults with obesity and diabetes.

  Recruiting University of Florida · Gainesville, Florida · NCT06861790

• How starting a GLP-1 medicine changes food reactions and choices.

  We will see if starting a GLP-1 medication changes how adults with overweight or obesity react to food and the foods they choose.

  Recruiting Penn State University · State College, Pennsylvania · NCT06843512

• Tirzepatide effects on muscle and blood-vessel health in older adults with obesity

  This trial will try tirzepatide for six months in adults 50 and older with obesity but without diabetes to see if it changes muscle mass, strength, and blood vessel health.

  Recruiting Phase 2 The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT06811324

• Effects of CONTRAVE on weight loss and behavior in adults with obesity

  This study is testing if the weight-loss drug CONTRAVE can help adults with obesity lose weight and manage their appetite better when combined with a diet.

  Recruiting at 3 sites Phase 4 The Royal's Institute of Mental Health Research · Ottawa, Ontario and 2 other locations · NCT06809166

• Optimizing extended care to help people keep weight off

  This program will test which combination of four low‑burden supports helps adults with obesity who have lost weight keep that weight off.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06785064

• Family-centered weight loss program for Black adults

  This study is testing a weight loss program for Black adults that involves family support to see which family activities help them lose weight best over six months.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT06724406

• Lifestyle changes for older adults with metabolic syndrome and tinnitus

  This study is testing whether lifestyle changes like exercise and a low-calorie diet can help older adults with obesity, metabolic syndrome, and tinnitus feel better and improve their health.

  Recruiting at 2 sites Cairo University · Dokki, Giza Governorate and 1 other locations · NCT06702085

• Exploring how gut bacteria affect weight regain after losing weight

  This study tests whether taking antibiotics after losing weight can help people keep the weight off by looking at how gut bacteria play a role in weight maintenance.

  Recruiting Weizmann Institute of Science · Rehovot · NCT06681246

• Tailoring TOPS for breast cancer survivors

  Aims to see if a community-based weight loss program (TOPS) can be made more relevant for women who have survived breast cancer.

  Recruiting Duke University · Durham, North Carolina · NCT06658912

• Sleep2BWell: adding sleep health to diet and activity for better blood pressure

  This program will try adding a sleep-health module to a community diet-and-exercise program to see if it helps adults with elevated blood pressure in underserved New York City neighborhoods.

  Recruiting at 2 sites Columbia University · New York, New York and 1 other locations · NCT06565104

• Diet-management app and smart scale for weight loss in people with heart failure and obesity

  This tests whether using a diet-management phone app at each meal plus a smart weight scale daily for 12 months helps people with heart failure and obesity live longer, avoid hospital stays, and feel less frail.

  Recruiting at 19 sites Heart Health Research Center · Beijing, Beijing Municipality and 25 other locations · NCT06455878

• Impact of weight loss on heart function in obese patients with heart failure

  This study is testing if losing weight with the help of a medication and a special diet can improve heart function and quality of life for obese patients with heart failure.

  Recruiting Phase 2/3 Hvidovre University Hospital · Copenhagen · NCT06423599

• Lifestyle changes to improve weight and fertility in obese men

  This study is testing whether a low-carb diet and health education can help obese men aged 22-40 lose weight and improve their fertility.

  Recruiting Third Affiliated Hospital of Zhengzhou University · Zhengzhou, Henan · NCT06339840

• Effects of a diet with essential amino acids on weight loss in obese patients

  This study is testing if adding essential amino acids to a low-calorie diet can help obese people lose weight while keeping their muscle mass.

  Recruiting Istituto Auxologico Italiano · Oggebbio, Verbania · NCT06309563

• Database for studying obesity and metabolic surgery outcomes in China

  This study is collecting information from people in China who have obesity and are having weight loss surgery to see how well these surgeries work in the long run.

  Recruiting Jinan University Guangzhou · Guangzhou, Guangdong · NCT06275061

• A new approach to help young adults lose weight

  This study is testing a new program that uses technology and coaching to help young adults aged 18 to 40 lose weight over six months.

  Recruiting University of Chicago · Chicago, Illinois · NCT06230744

• Understanding genetic factors that affect weight loss after bariatric surgery

  This study is trying to find out if certain genes can help predict how well people with severe obesity will lose weight after having bariatric surgery.

  Recruiting Institut de Recerca Biomèdica de Lleida · Lleida, Leida · NCT06226194

• Effects of Phaseolus vulgaris extract on weight and metabolism

  This study is testing if an extract from kidney beans can help people lose weight and improve their metabolism over 12 weeks compared to a placebo.

  Recruiting IBSA Farmaceutici Italia Srl · Catania, Catania · NCT06193577

• Endoscopic sleeve gastroplasty for people with obesity and MASH

  This study will test whether endoscopic sleeve gastroplasty plus lifestyle changes helps adults with obesity and MASH lose weight and improve liver health compared with lifestyle changes alone.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06138821

• Examining brain changes in cancer-related weight loss

  This study is trying to see how cancer-related weight loss affects the brain's ability to control appetite and motivation by comparing people with cancer to healthy volunteers.

  Recruiting University of Cambridge · Cambridge · NCT06112964

• Weight changes in male prisoners in Martinique

  This study looks at how the weight of male prisoners in Martinique changes from when they arrive to three months later and what factors like exercise, diet, and mental health might affect those changes.

  Recruiting University Hospital Center of Martinique · Ducos · NCT05982132

• Effects of weight loss with and without exercise on metabolic health

  This study is testing whether losing weight with exercise helps improve metabolic health more than just losing weight through dieting alone for people with obesity.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT05806801

• Weight loss before pregnancy to reduce childhood obesity risk

  This study is testing if losing 10% of their weight before getting pregnant can help healthy couples with an overweight mother reduce the risk of their child becoming overweight later on.

  Recruiting University of Aarhus · Aarhus · NCT05798494

• Switching a failed sleeve gastrectomy to SADI-S, RYGB, or OAGB

  This tests three surgical options—SADI-S, RYGB, and OAGB—for people who regained weight after a sleeve gastrectomy to see which gives the best weight loss, complication profile, and nutritional outcomes.

  Recruiting General Committee of Teaching Hospitals and Institutes, Egypt · Alexandria, Alexandria Governorate · NCT05608772

• Weight loss app for adolescents

  This study is testing a new smartphone app to help teenagers with obesity cut down on overeating by getting their feedback during the development process.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT05530538

• Weight loss and fitness program for active duty women after pregnancy

  This study is testing if a special diet plan can help active duty women who just had a baby lose weight and get fit during their first year after giving birth.

  Recruiting at 2 sites Tripler Army Medical Center · Honolulu, Hawaii and 1 other locations · NCT05518604

• Investigating weight loss after mini gastric bypass with a special ring

  This study is testing if a special ring used during mini gastric bypass surgery can help people lose a lot of weight and improve health issues related to obesity over five years.

  Recruiting Ziekenhuisgroep Twente · Almelo · NCT05472922

• Effects of exercise on fat tissue in obese individuals

  This study tests how exercise affects fat tissue in people with obesity to see if it can help improve their metabolism and manage weight better.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT04812314

• Registry for Endoscopic Bariatric Therapies

  This study is collecting information to see how well different non-surgical weight loss treatments work for people who can't have traditional weight loss surgery.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT04494048

• Interdisciplinary therapy for obesity management

  This study is testing different weight loss methods, like special diets and surgery, to see how they affect obesity and gut health over three years.

  Recruiting at 3 sites University of Hohenheim · Heidelberg and 2 other locations · NCT01344525

NIH-funded research (newest 40 of 154)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Predicting Weight Regain After Weight Loss Through Body Signals

  A study with people who are losing weight will check how their body’s metabolism and appetite signals might influence if they regain weight later.

  NIH research Drexel University · Philadelphia, United States · NIH-11554839

• Engaging men in weight loss with a game-based mental training and app program

  A game-based mobile program designed for American men to help them lose weight by combining engaging gaming features with brain training.

  NIH research Oregon Research Institute · Springfield, UNITED STATES · NIH-11496318

• Simplifying dietary self-monitoring to boost weight loss success

  A study tests a lighter, easier way to track food to help adults with overweight or obesity lose weight through a digital program.

  NIH research Stanford University · Stanford, United States · NIH-11450119

• Activin signaling in muscles, aging, and weight loss

  Aims to understand how activin signals in muscle affect aging, weight loss, and daily function, especially in older adults.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11446314

• How the brain drives overeating and weight loss with GLP-1 medications

  Scientists are studying how brain circuits that control food seeking respond to obesity and weight loss with a GLP-1 drug, to understand why weight loss often doesn’t hold.

  NIH research Rutgers, the State Univ of N.j. · Piscataway, United States · NIH-11435580

• Off-Ramp Feasibility: finding better ways to taper GLP-1 obesity medicines without weight regain

  A small, patient-friendly trial tests how to taper off GLP-1 obesity medicines without quickly regaining weight.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11425980

• Alpha cells, obesity, weight loss, and blood sugar control

  This grant looks at how alpha cells (parts of the pancreas) affect blood sugar during obesity and after weight loss, to help people with type 2 diabetes.

  NIH research University of California at Davis · Davis, United States · NIH-11425782

• New drug to prevent muscle loss and aid weight loss in older adults

  A new adjunct medicine is being tested to prevent muscle loss and support weight loss in adults, especially older adults.

  NIH research Ridgeline Therapeutics, INC. · Houston, UNITED STATES · NIH-11419676

• Healthy Dads, Healthy Kids — weight loss for Hispanic fathers and more active children

  This program helps Hispanic fathers lose weight while getting their elementary-age children more active through fun, family-focused sessions.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11415229

• SMARTer weight loss management

  A study is testing a smartphone app-based weight loss program, with optional coaching and stepped-up components, to help adults with overweight or obesity lose weight in a scalable, resource-smart way.

  NIH research Florida State University · Tallahassee, United States · NIH-11413557

• Making daily dietary goals easier to stick to with a mobile weight-loss program

  This grant tests a mobile weight-loss program for adults to help them follow dietary plans more consistently and lose weight.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11411095

• Sleep extension to boost weight loss in young adults

  A study tests whether adding more sleep to a calorie- and activity‑focused weight loss program helps overweight young adults lose more weight.

  NIH research University of Chicago · Chicago, United States · NIH-11398984

• Adapting Future Thinking to Help Weight Loss

  A patient-friendly program tests if imagining future outcomes can help people with obesity make better food choices and lose weight.

  NIH research Miriam Hospital · Providence, United States · NIH-11398584

• Family-centered Weight Loss for Black Adults: Optimizing and Evaluating with MOST and Social Networks

  A family-focused approach is being tested to help Black adults lose weight through more effective behavior changes and social support.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11397700

• Piloting a patient navigator to help adults use proven weight-loss options

  A patient navigator program will help adults with overweight or obesity start and stick with proven weight-loss options that fit their needs.

  NIH research Drexel University · Philadelphia, United States · NIH-11397621

• Weight-loss maintenance: using real-time data to tailor behavioral support

  A weight-management program uses real-time prompts and personalized support to help adults keep weight off after initial loss.

  NIH research Miriam Hospital · Providence, United States · NIH-11393706

• Weight-loss approach to Alzheimer’s risk in adults with Down syndrome

  A weight-loss program using a structured diet and behavioral support is being studied to see if it can reduce the risk or delay the onset of Alzheimer’s disease in adults with Down syndrome who are 21 or older.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11393156

• Exercise and bone-strengthening medication to protect bones during weight loss in older adults

  A year-long study will test whether resistance training, bone-loading exercise, and a common osteoporosis drug can help older adults lose weight without losing bone density.

  NIH research Wake Forest University · Winston-Salem, United States · NIH-11392386

• Targeting stress systems to boost how well weight-loss medicines work

  This grant explores how stress hormones interact with weight-loss drugs to make weight loss more effective and longer-lasting for adults.

  NIH research Georgia State University · Atlanta, United States · NIH-11391470

• Understanding why weight loss plateaus in people with obesity

  A study with adults to understand why body weight often stops dropping after initial loss and what brain and body signals are involved.

  NIH research University of Washington · Seattle, United States · NIH-11391109

• Remote yoga for long-term weight loss

  A remote yoga program added to an online weight-loss plan aims to help adults keep off weight for longer.

  NIH research Miriam Hospital · Providence, United States · NIH-11387920

• Using genetics and metabolism to personalize weight-loss diets

  This project looks at whether genetic and blood-based metabolic information can help tailor weight-loss diets to reduce after-meal blood sugar spikes and hunger for people trying to lose weight.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11385311

• A weight‑loss program in primary care using free online tools

  A primary care–based program helps adults use free online tools and a commercial app to set goals, monitor meals and activity, and connect with online weight‑loss communities to lose weight.

  NIH research University of Florida · Gainesville, United States · NIH-11382087

• Remote weight loss options: which approach works best for you

  A study tests two remote weight loss formats, with or without coaching, to see which helps adults (including African American participants) lose weight over a year.

  NIH research Miriam Hospital · Providence, United States · NIH-11381933

• Increase use of evidence-based weight loss care in adults

  This grant tests a brief, tailored pre-appointment tool that helps adults start weight-loss treatment by engaging patients and their doctors to encourage initiation of evidence-based programs.

  NIH research University of Florida · Gainesville, United States · NIH-11381872

• Personalized cash rewards to help adults lose weight

  This project uses smart computer algorithms to send personalized small cash rewards to adults to help them keep healthy habits and lose weight.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11377457

• Weight-loss program for Latina breast cancer survivors using remote, community-driven methods

  A remote, community-driven weight-loss program tailored for Latina breast cancer survivors will test adaptive, evidence-based strategies to help participants lose weight and improve health.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11376158

• Stepped care digital program to keep weight off after loss

  A Johns Hopkins team is testing a digital, stepped-care approach to help people keep at least 5% of their weight off after an initial loss.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11374489

• Human-centered design to improve coaching for small weight regain during weight loss maintenance

  A small, patient-friendly coaching program is being refined to help people bounce back quickly after a tiny weight regain during weight loss maintenance.

  NIH research Miriam Hospital · Providence, United States · NIH-11372281

• Time-restricted eating for weight loss maintenance in adults with obesity/diabetes risk

  A plan to test whether limiting eating to a short daily window helps adults who recently lost weight keep it off over time.

  NIH research New York University School of Medicine · New York, United States · NIH-11372240

• Improving Sleep to Help Weight Loss in Breast Cancer Survivors

  A study tests whether improving sleep with a proven therapy helps breast cancer survivors lose more weight when they start a weight loss program.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11365036

• CoachToFit: A weight-loss program for people with serious mental illness

  This program uses a smartphone app plus weekly phone support from a peer wellness coach to help people with serious mental illness lose weight.

  NIH research Veterans Health Administration · Pittsburgh, United States · NIH-11350383

• Understanding how stress affects weight loss during a lifestyle program

  A study at a Kansas medical center looks at how daily stress and coping influence how much weight people lose in a behavioral weight loss program.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11348185

• Glycemic and Weight Loss Effects of Semaglutide in People with Spinal Cord Injury and Type 2 Diabetes

  This study tests whether semaglutide can improve blood sugar control and help with weight loss in adults who have both spinal cord injury and type 2 diabetes.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11345560

• Exercise and fat tissue: how workouts change fat tissue and metabolic health during weight loss and regain

  A study to understand how adding exercise to a weight loss plan affects fat tissue and overall metabolic health in people with obesity.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11345409

• Behavioral economics approach to keeping weight off after weight loss

  A team at the University of Connecticut is testing a two-arm behavioral economics program to help adults with obesity maintain weight loss and reduce related health risks.

  NIH research University of Connecticut Storrs · Storrs-Mansfield, United States · NIH-11344239

• Weight-loss program for rural adults with obesity

  A randomized trial will compare a brain-friendly, acceptance-based weight-loss program to standard behavioral treatment for adults in under-resourced rural areas who have obesity.

  NIH research Trustees of Indiana University · Bloomington, United States · NIH-11342838

• A scalable plan to help people keep weight off after stopping obesity medications

  A new pilot program helps adults keep weight off after stopping GLP-1 medications or other anti-obesity drugs by using structured eating, activity, and mind-based practices.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11342005

• Using genetic scores to better predict how weight loss changes metabolic risk

  A study to see if genetic information can help predict who will have bigger health benefits from weight loss in adults with type 2 diabetes or related metabolic issues.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11341635

• Understanding Why Weight Comes Back After Losing It

  This project aims to understand why people regain weight after successfully losing it, by looking at how their body's appetite and metabolism change.

  NIH research Drexel University · Philadelphia, United States · NIH-11334136

Related topics

Quick answers

How many Weight Loss clinical trials are recruiting right now?

53, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in United States (24 trials), China (10 trials), Italy (3 trials), Egypt (2 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 2: 2, Phase 2/3: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →