Investigating how RNA modifications in fat cells affect metabolic diseases
Official title: Role of adipose mRNA modifications in metabolic disease
Funded at University of Michigan at Ann Arbor · NIH-11043323 · Data updated 2026-11-12
This study is looking at how certain changes in RNA in fat tissue might affect metabolism and contribute to obesity and diabetes, using specially modified mice to help find new ways to treat these conditions that could benefit people like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | March 1, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $474,240 |
| NIH project number | 5R01DK130111-04 |
| Project ID | NIH-11043323 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals struggling with obesity or metabolic disorders, particularly those with adult-onset diabetes.
✕Less likely to help
Patients who are not affected by obesity or metabolic diseases may not receive any benefit from this research.
What this research studies
This research explores the role of specific RNA modifications in adipose (fat) tissue and how they influence metabolic diseases like obesity and diabetes. By studying genetically modified mice, the researchers aim to understand how these RNA changes affect the secretion of proteins that regulate metabolism. The approach involves examining the effects of these modifications on fat cell function and their potential impact on overall health. Patients may benefit from insights that could lead to new treatments for obesity-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing obesity and related metabolic diseases.
How similar studies have gone: While the specific focus on RNA modifications in adipose tissue is relatively novel, similar approaches have shown promise in other areas of metabolic research.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Rui, Liangyou — University of Michigan at Ann Arbor
- Study coordinator: Rui, Liangyou
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.