Condition

Dexmedetomidine clinical trials and research

• 38Clinical trials
• 7NIH research projects
• 11Countries

Newest Dexmedetomidine clinical trials

All recruiting trials (38)

• Dexmedetomidine to See if Delirium Drops After Hip Fracture Surgery

  This observational study tests whether using dexmedetomidine around hip fracture surgery helps prevent postoperative delirium in adults 65 and older.

  Recruiting Aarhus University Hospital · Aarhus · NCT07867899

• Esmolol vs Dexmedetomidine for opioid-sparing in laparoscopic gynecologic surgery

  This study tests whether low-dose esmolol or dexmedetomidine, given during surgery, reduces opioid use and improves pain control after laparoscopic hysterectomy compared with placebo.

  Recruiting National and Kapodistrian University of Athens · Athens · NCT07846722

• Dexmedetomidine with taVNS to see if PTSD after trauma surgery can be reduced

  This study tests whether giving dexmedetomidine together with transcutaneous vagus nerve stimulation after emergency trauma surgery can lower the chances of developing PTSD.

  Recruiting Affiliated Hospital of Nantong University · Nantong, Jiangsu · NCT07813962

• Dexmedetomidine vs magnesium as intraperitoneal add-ons to bupivacaine for laparoscopic gallbladder removal

  This study tests whether adding dexmedetomidine or magnesium sulfate to bupivacaine injected inside the abdomen provides better pain relief after laparoscopic cholecystectomy for adults without serious health issues.

  Recruiting Alexandria University · Alexandria · NCT07693621

• Dexmedetomidine vs magnesium with lidocaine for eye block during DCR surgery

  This trial tests whether adding dexmedetomidine or magnesium sulfate to lidocaine for a preemptive peribulbar block can better manage blood pressure and heart rate in adults undergoing DCR surgery under general anesthesia.

  Recruiting Cairo University · Cairo · NCT07675616

• Dexmedetomidine vs Lignocaine to blunt intubation stress in cardiac surgery

  This trial tests whether giving dexmedetomidine or lignocaine before airway placement reduces heart and blood pressure changes during intubation in high-risk cardiac surgery patients.

  Recruiting Phase 4 Rawalpindi Institute of Cardiology · Rawalpindi, Punjab Province · NCT07611890

• Dexmedetomidine or Clonidine added to spinal anesthesia for cesarean delivery

  This study tests whether adding dexmedetomidine or clonidine to spinal anesthesia for cesarean delivery improves intraoperative comfort and analgesia.

  Recruiting Phase 4 Columbia University · New York, New York · NCT07567495

• Sedation with dexmedetomidine, propofol, or both during cataract surgery

  This project will test whether dexmedetomidine, propofol, or their combination (each given with fentanyl) provides the best sedation, safety, and surgeon satisfaction for adults having cataract surgery.

  Recruiting Saint-Joseph University · Beirut · NCT07556133

• Intranasal dexmedetomidine‑esketamine for pain relief after adenoid and tonsil surgery in children

  This trial will test whether giving children aged 3–7 a combined dexmedetomidine and esketamine nasal dose reduces pain after adenoid and tonsil surgery.

  Recruiting Phase 4 Peking University First Hospital · Beijing, Beijing Municipality · NCT07479602

• Propofol-only vs dexmedetomidine-propofol for sedation in children undergoing MRI

  This study tests whether using dexmedetomidine with propofol works better or differently than propofol alone for sedating kids during MRI.

  Recruiting Phase 4 Boston Children's Hospital · Boston, Massachusetts · NCT07369128

• Virtual reality versus IV dexmedetomidine to reduce maternal anxiety during cesarean delivery

  This study will test whether virtual reality or an IV dexmedetomidine infusion better reduces anxiety, stabilizes blood pressure and heart rate, and improves newborn breathing and heart rate in women having elective cesarean delivery under neuraxial anesthesia.

  Recruiting Benha University · Banhā, Benha · NCT07343843

• Dexamethasone, Dexmedetomidine, or Both After Laparoscopic Gallbladder Surgery

  This study tests whether dexamethasone, dexmedetomidine, or the combination help recovery of gut function after laparoscopic cholecystectomy.

  Recruiting Benha University · Banhā · NCT07329933

• IV lidocaine versus IV dexmedetomidine for pain control during sleeve gastrectomy

  It tests whether an IV infusion of lidocaine or dexmedetomidine given during laparoscopic sleeve gastrectomy helps reduce early postoperative pain and the need for opioid pain medicines in adults aged 20–50 with BMI 35–50.

  Recruiting Alexandria University · Alexandria · NCT07327905

• Dexmedetomidine and esketamine given around surgery to improve recovery after general anesthesia

  This trial will test whether giving dexmedetomidine, esketamine, or both during the perioperative period helps adults recover better after surgery under general anesthesia.

  Recruiting Phase 4 Peking University First Hospital · Beijing, Beijing Municipality · NCT07308756

• Intrathecal dexmedetomidine plus fentanyl with bupivacaine for spinal anesthesia during above-knee amputation

  This trial will test whether adding intrathecal dexmedetomidine to fentanyl and bupivacaine gives better and longer pain relief after above-knee amputation for adults with lower-limb sarcoma.

  Recruiting National Cancer Institute, Egypt · Cairo · NCT07276867

• Pregabalin plus dexmedetomidine for reducing pain and improving sleep in fibromyalgia

  This trial will try combining pregabalin with dexmedetomidine to reduce pain and improve sleep in adults with moderate-to-severe fibromyalgia.

  Recruiting Beijing Tiantan Hospital · Beijing · NCT07230197

• Timing of a single dexmedetomidine dose before laryngoscopy and intubation and its effect on stress response.

  This trial will test whether giving one dose of dexmedetomidine earlier or closer to surgery can reduce the blood pressure and heart rate changes caused by laryngoscopy and intubation in adults aged 18–65 with ASA I–II.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07165483

• Lidocaine versus dexmedetomidine during abdominal surgery to protect brain oxygen and reduce delirium in older adults

  This trial tests whether giving lidocaine or dexmedetomidine during major abdominal surgery helps keep brain oxygen levels stable and reduces postoperative delirium in people aged 65 and older.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07108764

• Dexmedetomidine to reduce agitation during ventilator weaning

  This trial will try dexmedetomidine to see if it reduces agitation in adult ICU patients who are ready to be weaned from mechanical ventilation.

  Recruiting Sohag University · Sohag · NCT07066605

• Remimazolam, dexmedetomidine, or esketamine to calm young children before surgery

  This trial will test which of three drugs—remimazolam, dexmedetomidine, or esketamine—best calms children aged 2–5 before adenotonsillectomy and reduces postoperative agitation.

  Recruiting Maternal and Child Health Hospital of Hubei Province · Wuhan, Hubei · NCT07050212

• Comparing dexmedetomidine and bupivacaine for pain management after brain surgery

  This study is testing if adding dexmedetomidine to bupivacaine can help reduce pain better after brain surgery compared to using bupivacaine alone.

  Recruiting Ain Shams University · Cairo · NCT06993922

• Comparing dexmedetomidine and lidocaine for pain management after mastectomy

  This study is testing whether dexmedetomidine or lidocaine works better for managing pain after mastectomy surgery in adults aged 18 to 75.

  Recruiting Cairo University · Cairo · NCT06910644

• Combining dexmedetomidine and esketamine to improve sleep after major surgery

  This study is testing whether a mix of two medications, dexmedetomidine and esketamine, can help adults sleep better after major surgery compared to a placebo.

  Recruiting Phase 4 Peking University First Hospital · Beijing · NCT06859892

• Using dexmedetomidine and esketamine for sedation in young children before surgery

  This study tests if a combination of two medications, dexmedetomidine and esketamine, can help young children feel calm and relaxed before surgery.

  Recruiting Phase 4 Second Affiliated Hospital of Wenzhou Medical University · Wenzhou, Zhejiang and 1 other locations · NCT06853431

• Effects of dexmedetomidine and esketamine on sleep after cardiac surgery

  This study tests whether the medications dexmedetomidine or esketamine can help improve sleep for people recovering from heart surgery.

  Recruiting Phase 4 Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu and 1 other locations · NCT06778811

• Dexmedetomidine infusion to reduce intraoperative remifentanil use during laparoscopic abdominal surgery

  This trial tests whether giving a dexmedetomidine infusion during laparoscopic abdominal surgery can lower the amount of remifentanil needed during the operation.

  Recruiting Ciusss de L'Est de l'Île de Montréal · Montreal, Quebec · NCT06684197

• Using Dexmedetomidine and Esketamine to Reduce Bladder Discomfort from Catheters

  This study is testing if the combination of two medications, dexmedetomidine and esketamine, can help reduce bladder discomfort caused by catheters in patients having urological surgery.

  Recruiting at 2 sites Phase 4 Peking University First Hospital · Beijing, Beijing Municipality and 1 other locations · NCT06399185

• Effects of anesthetics on brain connectivity in glioma patients

  This study tests how different types of anesthesia affect brain connections in patients having surgery for a brain tumor to see if it impacts their thinking and recovery afterward.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT06138340

• Pain relief for carpal tunnel syndrome using Dexmedetomidine, Ozone, and Dexamethasone injections

  This study is testing a new combination of injections to see if it can relieve pain better for people with carpal tunnel syndrome compared to standard treatments.

  Recruiting Tanta University · Tanta, El Gharbia · NCT06133712

• Esketamine dose levels combined with dexmedetomidine to reduce pain after scoliosis correction

  This study will test whether different doses of esketamine given with dexmedetomidine and opioids can reduce immediate postoperative pain and lower the chance of chronic postsurgical pain in adults having scoliosis correction.

  Recruiting Phase 4 Peking University First Hospital · Beijing, Beijing Municipality · NCT06087510

• Evaluating the effects of dexmedetomidine in outpatient surgery anesthesia

  This study is testing if using dexmedetomidine instead of opioids during outpatient surgeries can help patients feel better and wake up more smoothly after anesthesia.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes · NCT06082856

• Using intranasal dexmedetomidine to manage pain during eye exams in premature infants

  This study tests if a nasal spray of dexmedetomidine can help reduce pain for premature infants during eye exams.

  Recruiting Phase 3 Assaf-Harofeh Medical Center · Be’er Ya‘aqov, Center · NCT06067958

• Using dexmedetomidine to improve long-term survival after cancer surgery in older patients

  This study tests if giving older patients a medication called dexmedetomidine during cancer surgery can help them recover better and live longer.

  Recruiting at 34 sites Peking University First Hospital · Hefei, Anhui and 39 other locations · NCT06030804

• Using dexmedetomidine and fentanyl for pain control after major abdominal surgery

  This study is testing a new pain management method using a special device that gives patients dexmedetomidine and fentanyl after major abdominal surgery to see if it helps control pain better while using less opioids.

  Recruiting Korea University Guro Hospital · Seoul · NCT05672225

• Treating delirium after coronary bypass with pregabalin versus dexmedetomidine

  This study will test whether pregabalin or dexmedetomidine works better to treat delirium in patients aged 65 and older after coronary artery bypass grafting.

  Recruiting Phase 4 Tanta University · Tanta, El-Gharbia Governorate · NCT05640453

• Erector spinae plane block for managing pain after breast cancer surgery

  This study is testing if a special nerve block combined with a medication can help reduce pain and improve recovery for women after breast cancer surgery.

  Recruiting at 2 sites Peking University First Hospital · Beijing, Beijing Municipality and 1 other locations · NCT05494502

• Using Dexmedetomidine to Reduce Delirium After Awake Brain Surgery

  This study is testing if a medication called dexmedetomidine can help prevent confusion after brain surgery in patients who are awake during the procedure.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT05195034

• Effects of Dexmedetomidine on cognitive recovery after cardiac surgery

  This study is testing if a medication called Dexmedetomidine can help people recover their thinking skills better after having heart surgery.

  Recruiting at 3 sites Phase 4 Sunnybrook Health Sciences Centre · Vancouver, British Columbia and 7 other locations · NCT04289142

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Naloxone-DEXmedetomidine combo to calm methamphetamine agitation in polysubstance use

  A study at Marshall University tests whether a naloxone and dexmedetomidine combination can safely and effectively reduce agitation in people acutely intoxicated with methamphetamine and other substances.

  NIH research Marshall University · Huntington, UNITED STATES · NIH-11420634

• Dexmedetomidine Sublingual Film for Flare-Ups in Familial Dysautonomia

  A new dexmedetomidine pill under the tongue is being tested to help people with familial dysautonomia manage sudden sympathetic flare-ups at home.

  NIH research New York University School of Medicine · New York, United States · NIH-11361421

• Dexmedetomidine Sublingual Film for Autonomic Crises in Familial Dysautonomia

  This project looks at using a sublingual film medication to help people with familial dysautonomia manage sudden, severe changes in blood pressure and heart rate at home.

  NIH research New York University School of Medicine · New York, United States · NIH-11177687

• Preventing Confusion After Heart Surgery with a Special Sleep Medication

  This project looks at whether a medication called dexmedetomidine can help prevent confusion and memory problems in older patients after heart surgery.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11116932

• New treatment for severe autonomic crises in patients with familial dysautonomia

  This study is looking at a new way to help people with familial dysautonomia manage sudden, severe symptoms using a special film that dissolves under the tongue, which could make it easier and safer for them to handle these episodes at home.

  NIH research New York University School of Medicine · New York, United States · NIH-10932210

• Using low doses of dexmedetomidine to treat respiratory failure from fentanyl overdose

  This study is looking at how a small amount of a brain medication called dexmedetomidine can help people breathe normally again after they've had trouble breathing from a fentanyl overdose.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-10701905

• Using a new medication to help treat opioid withdrawal symptoms

  This study is looking at a new film you place under your tongue that contains a medication called dexmedetomidine to help ease withdrawal symptoms for people dealing with opioid use disorder, especially those using strong opioids like fentanyl, and it aims to find out if this treatment is safe and works better than cur

  NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-10478324

Related topics

Quick answers

How many Dexmedetomidine clinical trials are recruiting right now?

38, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in China (14 trials), Egypt (13 trials), Canada (2 trials), United States (2 trials), Pakistan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 12, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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