Dexmedetomidine vs magnesium as intraperitoneal add-ons to bupivacaine for laparoscopic gallbladder removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares two intraperitoneal adjuvants mixed with bupivacaine during laparoscopic cholecystectomy to see which offers better postoperative analgesia. The design uses two arms: bupivacaine 100 mg with dexmedetomidine 1 mcg/kg and bupivacaine 100 mg with magnesium sulfate 50 mg/kg. Eligible participants are adults aged 18-60 with ASA I-II undergoing elective laparoscopic cholecystectomy under general anesthesia. Outcomes focus on analgesic effectiveness and safety, contributing to multimodal pain strategies in this common procedure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 18-60 years
* ASA physical status I-II
* scheduled for elective laparoscopic cholecystectomy under general anesthesia.

Exclusion Criteria:

* Known hypersensitivity to study drugs
* history of cardiac arrhythmias or conduction abnormalities
* severe hepatic/renal impairment
* chronic opioid or analgesic use
* pregnancy
* conversion to open surgery
* drain insertion.

Where it's running

• Alexandria University
  Alexandria, Egypt Recruiting

Study contacts

• Principal investigator: sarah m elgamal, MD — Alexandria University
• Study coordinator: sarah m elgamal, MD
• Email: sarahelgamal1990@yahoo.com
• Phone: 01005496440

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Dexmedetomidine to See if Delirium Drops After Hip Fracture Surgery

  This observational study tests whether using dexmedetomidine around hip fracture surgery helps prevent postoperative delirium in adults 65 and older.

  Recruiting Aarhus University Hospital · Aarhus · NCT07867899

• Esmolol vs Dexmedetomidine for opioid-sparing in laparoscopic gynecologic surgery

  This study tests whether low-dose esmolol or dexmedetomidine, given during surgery, reduces opioid use and improves pain control after laparoscopic hysterectomy compared with placebo.

  Recruiting National and Kapodistrian University of Athens · Athens · NCT07846722

• Subcostal TAP Block and EEG Changes During Laparoscopic Gallbladder Surgery

  This observational study tests whether adding a subcostal TAP block to standard IV opioid therapy affects intraoperative brain activity measures and pain needs in adults undergoing laparoscopic cholecystectomy.

  Recruiting Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital · Istanbul · NCT07818954

• Dexmedetomidine with taVNS to see if PTSD after trauma surgery can be reduced

  This study tests whether giving dexmedetomidine together with transcutaneous vagus nerve stimulation after emergency trauma surgery can lower the chances of developing PTSD.

  Recruiting Affiliated Hospital of Nantong University · Nantong, Jiangsu · NCT07813962

• Dexmedetomidine vs magnesium with lidocaine for eye block during DCR surgery

  This trial tests whether adding dexmedetomidine or magnesium sulfate to lidocaine for a preemptive peribulbar block can better manage blood pressure and heart rate in adults undergoing DCR surgery under general anesthesia.

  Recruiting Cairo University · Cairo · NCT07675616

• How different ventilator settings affect lung energy during gallbladder surgery

  This study tests whether two ventilator modes (VCV and PRVC) deliver different amounts of energy to the lungs in adults undergoing laparoscopic gallbladder removal.

  Recruiting Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital · Yenimahalle, Ankara · NCT07670494

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.