Effects of anesthetics on brain connectivity in glioma patients
Official title: The Alterations of Brain Network Connectivity Under Sedation and Anesthesia in Patients With Supratentorial Glioma
Run by Beijing Tiantan Hospital · NCT06138340 · Data updated 2026-11-12
This study tests how different types of anesthesia affect brain connections in patients having surgery for a brain tumor to see if it impacts their thinking and recovery afterward.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Beijing Tiantan Hospital Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | August 31, 2023 |
| Main results expected | November 30, 2025 |
| Study ends | December 31, 2025 |
| Registry record updated | February 14, 2025 |
| Trial ID | NCT06138340 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old diagnosed with unilateral supratentorial glioma who are right-handed and in good health.
✕Probably not a fit
Patients with a history of cerebrovascular disease, brain trauma, or those with severe cardiac or renal dysfunction may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates how different anesthetics, specifically dexmedetomidine, propofol, and remimazolam, influence brain network connectivity in patients undergoing surgery for unilateral supratentorial glioma. By utilizing advanced neuroimaging techniques, the study aims to uncover the mechanisms behind postoperative cognitive function and the incidence of delirium. The research focuses on patients aged 18 and older who are right-handed and meet specific health criteria, ensuring a controlled environment for analysis.
Why it matters
Potential benefit: If successful, this study could lead to improved anesthetic protocols that minimize cognitive impairment and delirium in brain tumor patients post-surgery.
How similar studies have gone: Previous studies have indicated that dexmedetomidine may reduce postoperative delirium, suggesting that this approach has potential based on earlier findings.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosed as unilateral supratentorial glioma by MRI * Selective operation * Age over 18 years old * ASA I-II * Right handedness Exclusion Criteria: * History of cerebrovascular disease, brain trauma, chemotherapy and radiotherapy, or psychotropic drugs * History of intracranial surgery * Drug and/or alcohol abuse * History of dementia or mental illness * Pregnant or lactating women * Contraindications for MRI * Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block * Severe hepatic or renal dysfunction
Where it's running
-
Beijing Tian Tan Hospital, Capital Medical University
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Study coordinator: Yuming Peng, MD,Ph.D
- Email: florapym766@163.com
- Phone: 8610-59976658
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.