Effects of anesthetics on brain connectivity in glioma patients
The Alterations of Brain Network Connectivity Under Sedation and Anesthesia in Patients With Supratentorial Glioma
This study tests how different types of anesthesia affect brain connections in patients having surgery for a brain tumor to see if it impacts their thinking and recovery afterward.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Beijing Tiantan Hospital Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT06138340 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how different anesthetics, specifically dexmedetomidine, propofol, and remimazolam, influence brain network connectivity in patients undergoing surgery for unilateral supratentorial glioma. By utilizing advanced neuroimaging techniques, the study aims to uncover the mechanisms behind postoperative cognitive function and the incidence of delirium. The research focuses on patients aged 18 and older who are right-handed and meet specific health criteria, ensuring a controlled environment for analysis.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old diagnosed with unilateral supratentorial glioma who are right-handed and in good health.
Not a fit: Patients with a history of cerebrovascular disease, brain trauma, or those with severe cardiac or renal dysfunction may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved anesthetic protocols that minimize cognitive impairment and delirium in brain tumor patients post-surgery.
How similar studies have performed: Previous studies have indicated that dexmedetomidine may reduce postoperative delirium, suggesting that this approach has potential based on earlier findings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosed as unilateral supratentorial glioma by MRI * Selective operation * Age over 18 years old * ASA I-II * Right handedness Exclusion Criteria: * History of cerebrovascular disease, brain trauma, chemotherapy and radiotherapy, or psychotropic drugs * History of intracranial surgery * Drug and/or alcohol abuse * History of dementia or mental illness * Pregnant or lactating women * Contraindications for MRI * Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block * Severe hepatic or renal dysfunction
Where this trial is running
Beijing, Beijing Municipality
- Beijing Tian Tan Hospital, Capital Medical University — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Study coordinator: Yuming Peng, MD,Ph.D
- Email: florapym766@163.com
- Phone: 8610-59976658
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.