Intrathecal dexmedetomidine plus fentanyl with bupivacaine for spinal anesthesia during above-knee amputation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 18–60 scheduled for above-knee amputation for lower-extremity sarcoma receive spinal anesthesia with hyperbaric bupivacaine and either fentanyl alone or fentanyl plus intrathecal dexmedetomidine. The study compares postoperative analgesia duration, block characteristics, and perioperative pain control between the two groups. Standard eligibility criteria exclude patients with contraindications to spinal anesthesia, significant cardiac arrhythmias, pregnancy, chronic pain disorders, or psychiatric illness. Procedures are performed at the National Cancer Institute in Cairo with perioperative monitoring and standardized anesthesia protocols.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age from 18 to 60 years.
* Both sexes.
* American Society of Anesthesiologists (ASA) physical status of II-III.
* Height between 150-185 cm.
* Body mass index between 18-35 kg/m².
* Scheduled for above-knee amputation due to lower limb sarcomas.

Exclusion Criteria:

* Allergy to any of the investigated drugs.
* History of heart block, arrhythmia, or ongoing therapy with beta- or calcium channel- blockers, or angiotensin-converting-enzyme inhibitors.
* Contraindications to spinal anesthesia.
* Pregnancy or lactation.
* Presence of psychiatric illness or chronic pain conditions.

Where it's running

• National Cancer Institute
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Mai M Elrawas, MD
• Email: mai.elrawas@nci.cu.edu.eg
• Phone: 00201222177242

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.