Timing of a single dexmedetomidine dose before laryngoscopy and intubation and its effect on stress response.
Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation? A Randomized Controlled Trial
NA · Tanta University · NCT07165483
This trial will test whether giving one dose of dexmedetomidine earlier or closer to surgery can reduce the blood pressure and heart rate changes caused by laryngoscopy and intubation in adults aged 18–65 with ASA I–II.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 45 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Tanta University (other) |
| Locations | 1 site (Tanta, El-Gharbia) |
| Trial ID | NCT07165483 on ClinicalTrials.gov |
What this trial studies
This interventional study compares a single preoperative dose of dexmedetomidine given at different time points with a saline control to see how timing affects the stress response to laryngoscopy and intubation. Adult patients (18–65 years) with ASA physical status I–II undergoing elective procedures will be assigned to receive dexmedetomidine at one of two preoperative timing windows or saline before induction. Investigators will monitor hemodynamic measures such as heart rate and blood pressure around laryngoscopy and intubation to compare responses between groups. Patients with major cardiovascular or respiratory disease, diabetes, hypertension, obesity, pregnancy, breastfeeding, sleep apnea, use of certain antihypertensive or heart-rate–affecting drugs, or those undergoing emergency procedures are excluded.
Who should consider this trial
Good fit: Adults aged 18–65 in good to moderate health (ASA I–II) scheduled for elective procedures and not taking interfering medications are ideal candidates.
Not a fit: Patients with severe cardiovascular or respiratory disease, diabetes, hypertension, obesity, pregnancy, breastfeeding, sleep apnea, or those on certain antihypertensive or heart-rate–altering medications are unlikely to be eligible or to benefit from this protocol.
Why it matters
Potential benefit: If successful, adjusting the timing of a single dexmedetomidine dose could help reduce the immediate blood pressure and heart rate spikes during laryngoscopy and intubation, improving hemodynamic stability around anesthesia.
How similar studies have performed: Previous studies have shown that dexmedetomidine can blunt the hemodynamic and stress responses to laryngoscopy and intubation, and this study focuses specifically on optimizing the timing of a single dose.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age from 18 to 65 years. * Both sexes. * American Society of Anesthesiology (ASA) physical status I-II. Exclusion Criteria: * Severe cardiovascular problems. * Respiratory disorders. * Diabetes. * Hypertension. * Obesity. * Allergic reaction to study drugs. * Patients on antihypertensive medication (α-methyldopa, clonidine, or other α2-adrenergic agonists) * Medications that affect heart rate (HR) or blood pressure (BP). * Pregnant. * Currently breast-feeding women. * History of sleep apnea. * Those for emergency procedures.
Where this trial is running
Tanta, El-Gharbia
- Tanta University — Tanta, El-Gharbia, Egypt (RECRUITING)
Study contacts
- Study coordinator: Mohammed S Elsharkawy, MD
- Email: mselsharkawy@med.tanta.edu.eg
- Phone: 00201148207870
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Time, Dexmedetomidine, Stress Response, Laryngoscopy, Intubation