Timing of a single dexmedetomidine dose before laryngoscopy and intubation and its effect on stress response.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares a single preoperative dose of dexmedetomidine given at different time points with a saline control to see how timing affects the stress response to laryngoscopy and intubation. Adult patients (18–65 years) with ASA physical status I–II undergoing elective procedures will be assigned to receive dexmedetomidine at one of two preoperative timing windows or saline before induction. Investigators will monitor hemodynamic measures such as heart rate and blood pressure around laryngoscopy and intubation to compare responses between groups. Patients with major cardiovascular or respiratory disease, diabetes, hypertension, obesity, pregnancy, breastfeeding, sleep apnea, use of certain antihypertensive or heart-rate–affecting drugs, or those undergoing emergency procedures are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age from 18 to 65 years.
* Both sexes.
* American Society of Anesthesiology (ASA) physical status I-II.

Exclusion Criteria:

* Severe cardiovascular problems.
* Respiratory disorders.
* Diabetes.
* Hypertension.
* Obesity.
* Allergic reaction to study drugs.
* Patients on antihypertensive medication (α-methyldopa, clonidine, or other α2-adrenergic agonists)
* Medications that affect heart rate (HR) or blood pressure (BP).
* Pregnant.
* Currently breast-feeding women.
* History of sleep apnea.
* Those for emergency procedures.

Where it's running

• Tanta University
  Tanta, El-Gharbia, Egypt Recruiting

Study contacts

• Study coordinator: Mohammed S Elsharkawy, MD
• Email: mselsharkawy@med.tanta.edu.eg
• Phone: 00201148207870

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.