Dexmedetomidine infusion to reduce intraoperative remifentanil use during laparoscopic abdominal surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial investigates whether an intraoperative infusion of dexmedetomidine, compared with placebo, reduces intraoperative remifentanil consumption in ASA I–III patients undergoing laparoscopic abdominal surgery. The regimen leverages dexmedetomidine’s sedative, analgesic, and sympatholytic properties to potentially spare opioids. The study builds on prior data suggesting opioid-sparing effects in various surgeries and aims to extend findings to ASA 3 patients undergoing laparoscopic procedures. Outcomes focus on intraoperative opioid use with consideration of safety and related hemodynamic effects. The trial is conducted at Hôpital Maisonneuve-Rosemont in Montreal, led by CIUSSS de l'Est de l'Île de Montréal.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ASA 1-3
* Laparascopic surgery (including general surgery, gynecology, urology) a small abdominal incision (less than 5 cm) will be tolerated.

Exclusion Criteria:

* Patient refusal
* Chronic use of opioids
* Allergy to medication used in the trial
* Pregnant or breastfeeding women
* Contraindications to dexmedetomidine (Bradycardia, arrythmia or pace- maker, severe ventricular dysfunction)

Where it's running

• Hôpital Maisonneuve-Rosemont
  Montreal, Quebec, Canada Recruiting

Study contacts

• Study coordinator: Olivier Verdonck
• Email: overdonck@gmail.com
• Phone: +15142523426

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.