Comparing dexmedetomidine and lidocaine for pain management after mastectomy
Dexmedetomidine Versus Lidocaine Infusions as Adjuvants to General Anesthesia for Chronic Pain Management After Mastectomy: A Randomized Controlled Trial
This study is testing whether dexmedetomidine or lidocaine works better for managing pain after mastectomy surgery in adults aged 18 to 75.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | Female |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06910644 on ClinicalTrials.gov |
What this trial studies
This study compares the effectiveness of dexmedetomidine and lidocaine infusions as adjuvants to general anesthesia in managing chronic pain following mastectomy. Chronic pain is a significant issue for patients undergoing breast cancer surgery, and this research aims to determine which infusion provides better pain relief. The study involves patients aged 18 to 75 who are scheduled for mastectomy with axillary dissection and evaluates the outcomes of both medications in a controlled setting.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 75 scheduled for mastectomy with axillary dissection due to breast cancer.
Not a fit: Patients with known allergies to the study drugs, hepatic or renal insufficiency, or those on certain medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients recovering from mastectomy.
How similar studies have performed: While there have been studies on the use of adjuvants in anesthesia, the specific comparison of dexmedetomidine and lidocaine in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age from 18 to 75 years. * American Society of Anesthesiologists (ASA) physical status II. * Scheduled for mastectomy with axillary dissection (either modified radical mastectomy with or without latissimus dorsi flap or conservative breast surgery) due to breast cancer. Exclusion Criteria: * Patient refusal. * Known allergy to any of the study drugs. * Those with hepatic or renal insufficiency. * Patients who are running regularly on B blockers. * α2 adrenergic agonists and sedatives. * Psychoactive medications.
Where this trial is running
Cairo
- Cairo University — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Mohamed E Abdel Fattah, MD
- Email: mohamed-elsaid@cu.edu.eg
- Phone: 00201284475792
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.