Using dexmedetomidine to improve long-term survival after cancer surgery in older patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of perioperative dexmedetomidine on long-term survival outcomes in older patients undergoing cancer surgery. It aims to determine whether administering dexmedetomidine during the surgical process can enhance recovery and reduce complications, thereby improving overall survival rates. The study will involve a multicenter randomized design, comparing outcomes between patients receiving dexmedetomidine and those receiving a placebo. The focus is on older patients, who are at higher risk for complications and poorer long-term survival after surgery.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. Aged 60 years or older.
2. Scheduled to undergo radical surgery for cancer under general anesthesia, with an expected surgical duration of 2 hours or longer.
3. Required patient-controlled intravenous analgesia after surgery.

Exclusion criteria:

1. Inability to communicate preoperatively due to visual, auditory, verbal. or other reasons.
2. Surgery for breast cancer or intracranial tumor.
3. Preoperative severe sinus bradycardia (\<50 beats per minute), sick sinus syndrome，or second-degree or above atrioventricular block without pacemaker.
4. Severe hepatic dysfunction (Child-Pugh class C).
5. Severe renal dysfunction (requirement of renal replacement therapy before surgery).
6. Enrolled in other clinical studies.

Where it's running

• The First Affiliated Hospital of China University of Science and Technology
  Hefei, Anhui, China Recruiting
• The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
  Hefei, Anhui, China Recruiting
• Peking University First Hospital
  Beijing, Beijing Municipality, China Recruiting
• Tsinghua University Yuquan Hospital
  Beijing, Beijing Municipality, China Recruiting
• Cancer Hospital Chinese Academy of Medical Sciences
  Beijing, Beijing Municipality, China Recruiting
• The First Affiliated Hospital of Army Medical University (Southwest Hospital)
  Chongqing, Chongqing Municipality, China Recruiting

Study contacts

• Principal investigator: Dong-Xin Wang, MD,PhD — Peking University First Hospital
• Study coordinator: Dong-Xin Wang, MD,PhD
• Email: wangdongxin@hotmail.com
• Phone: 8610 83572784

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.