Condition

Mastectomy clinical trials and research

• 29Clinical trials
• 6NIH research projects
• 17Countries

Newest Mastectomy clinical trials

All recruiting trials (29)

• Reverse Fly Exercise for Supraspinatus Tendinitis in Women on Aromatase Inhibitors After Mastectomy

  This study tests whether adding reverse fly exercises to standard tendonitis therapy helps relief in women aged 50–70 who had mastectomy and are on aromatase inhibitors.

  Recruiting Cairo University · Cairo · NCT07763080

• Transverse vs Longitudinal Serratus Anterior Plane Block for Breast Surgery

  This trial tests whether a longitudinal ultrasound view for serratus anterior plane block provides better pain relief after breast surgery than the standard transverse view.

  Recruiting Ankara Etlik City Hospital · Ankara, Yenimahalle\Ankara · NCT07739277

• Combined PECS II and PIP blocks vs TPVB for post-mastectomy pain relief

  This trial tests whether a combination of PECS II and superficial PIP blocks can provide better or similar pain relief after mastectomy compared with the standard thoracic paravertebral block.

  Recruiting Dharmais National Cancer Center Hospital · Jakarta, DKI Jakarta · NCT07738770

• Erector Spinae Block vs Paravertebral Block for Chronic Pain After Mastectomy

  This trial tests whether an erector spinae block can better prevent chronic pain after mastectomy than a paravertebral block in adults 18–80.

  Recruiting American University of Beirut Medical Center · Beirut · NCT07561411

• Same-day awake mastectomy with immediate prepectoral implant reconstruction

  This project tests whether the AMADeuS care pathway—awake same-day mastectomy with prepectoral implant reconstruction, opioid-sparing anesthesia, and telemedicine follow-up—controls pain and is as safe as usual hospital care for women having mastectomy.

  Recruiting University of Rome Tor Vergata · Rome, Rome · NCT07510698

• Comparing two ultrasound-guided chest wall nerve blocks for pain after mastectomy

  This study will see if one of two ultrasound-guided chest wall nerve blocks gives better pain relief and less opioid use for women having an elective mastectomy.

  Recruiting Uludag University · Bursa, Nilüfer · NCT07510269

• Amantadine or duloxetine added to pregabalin to prevent post-mastectomy pain

  This will see if adding amantadine or duloxetine to pregabalin around the time of modified radical mastectomy reduces the risk of long-term post-mastectomy pain in adults aged 18–65.

  Recruiting Cairo University · Cairo · NCT07421427

• Using indocyanine green to find sentinel lymph nodes during mastectomy

  This pilot will test whether injecting indocyanine green and using fluorescence during mastectomy can find sentinel lymph nodes in women with clinically node-negative invasive breast cancer.

  Recruiting at 2 sites St. Antonius Hospital · Zwolle, Overijssel and 1 other locations · NCT07362485

• Video-guided exercise program to help recovery after mastectomy

  This 16-week live small-group video exercise program will try to improve fitness, balance, and strength for adults who recently had a mastectomy.

  Recruiting University of California, San Diego · San Diego, California and 1 other locations · NCT07071896

• Nipple reconstruction with cross-linked hyaluronic acid after mastectomy

  This trial will test whether adding a cross-linked hyaluronic acid injection to areola micropigmentation helps women who had a mastectomy achieve better nipple projection, appearance, and satisfaction.

  Recruiting Germans Trias i Pujol Hospital · Badalona, Barcelona · NCT07008339

• Comparing dexmedetomidine and lidocaine for pain management after mastectomy

  This study is testing whether dexmedetomidine or lidocaine works better for managing pain after mastectomy surgery in adults aged 18 to 75.

  Recruiting Cairo University · Cairo · NCT06910644

• AI-supported education for patients undergoing mastectomy

  This study is testing whether an AI-supported education program can help reduce fear and anxiety in women getting a mastectomy for breast cancer compared to standard education.

  Recruiting Bezmialem Vakif University · Istanbul, Bakirköy · NCT06796166

• Patient-specific 3D-printed breast molds for shaping tissue during autologous reconstruction

  This project will test whether 3D-printed, patient-specific breast molds help surgeons shape tissue faster and more consistently during autologous breast reconstruction for adults after mastectomy.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT06711965

• Comparing two nerve-block options to reduce pain after total mastectomy.

  This test tries whether a PECS-II block given before surgery or a pectoral block given during surgery, using bupivacaine or liposomal bupivacaine, provides better pain control after total mastectomy for breast cancer or high-risk patients.

  Recruiting Phase 4 University of Cincinnati · Cincinnati, Ohio · NCT06574022

• Comparing preoperative and pathologic tumor sizes in breast cancer

  This study is trying to see if combining different tests and factors can help doctors better plan breast cancer surgeries by predicting how much of the tumor needs to be removed.

  Recruiting Incheon St.Mary's Hospital · Incheon · NCT06505577

• Bionic breast implant to restore touch and reduce chronic pain after mastectomy

  This project will try a bionic breast implant that stimulates nerves to restore touch and reduce chronic pain for adults having bilateral mastectomy with two-stage (tissue expander) reconstruction.

  Recruiting University of Chicago · Chicago, Illinois · NCT06382272

• Using Stellate Ganglion Block to Prevent Depression After Mastectomy

  This study tests whether a special nerve block can help prevent depression and pain in women who are having surgery for breast cancer.

  Recruiting Mansoura University · Al Mansurah · NCT06263907

• Upfront treatment for breast cancer with nodal metastases

  This study is testing if starting treatment with surgery and targeted therapy can help women with early-stage breast cancer that has spread to their lymph nodes live longer and have fewer recurrences.

  Recruiting at 3 sites Phase 2 Cedars-Sinai Medical Center · Los Angeles, California and 2 other locations · NCT06092892

• Pectoral nerve block versus thoracic paravertebral block to prevent chronic pain after mastectomy

  This trial will test whether a pectoral (PECS) block or a thoracic paravertebral (TPVB) block given during mastectomy better prevents long-term chest, axillary, or arm pain in adult women.

  Recruiting Assiut University · Asyut · NCT06082206

• Identifying risk factors for seroma formation after breast surgery

  This study is trying to find out which patients are more likely to develop fluid buildup after breast surgery so that doctors can give better advice and care to prevent it.

  Recruiting University Hospital Augsburg · Augsburg, Bavaria · NCT05899387

• Erector spinae plane block for managing pain after breast cancer surgery

  This study is testing if a special nerve block combined with a medication can help reduce pain and improve recovery for women after breast cancer surgery.

  Recruiting at 2 sites Peking University First Hospital · Beijing, Beijing Municipality and 1 other locations · NCT05494502

• Reducing post-mastectomy pain with opioid-free anesthesia

  This study is testing whether using anesthesia without opioids can help women who have had a mastectomy experience less chronic pain a year after their surgery compared to traditional opioid-based anesthesia.

  Recruiting Gangnam Severance Hospital · Seoul · NCT05146778

• Evaluating lidocaine infusions for managing post-operative pain in breast cancer surgery

  This study is testing if giving lidocaine infusions during and after breast cancer surgery can help women avoid long-lasting pain after their operation.

  Recruiting at 39 sites Phase 3 Monash University · Kingswood, New South Wales and 48 other locations · NCT05072314

• Comparing fat processing methods for breast reconstruction after mastectomy

  This study is testing which fat processing method works best for keeping fat grafts in place during breast reconstruction after mastectomy for women who have enough fat to use.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT04891510

• Repeat Sentinel Lymph Node Biopsy for Breast Cancer Recurrence

  This study is testing if a repeat lymph node biopsy can help patients with breast cancer that has come back after treatment by giving important information for their next steps in care.

  Recruiting Gangnam Severance Hospital · Seoul · NCT04741737

• Preventing lymphedema after breast cancer surgery

  This study is testing a new procedure to see if connecting lymph vessels can help prevent swelling in the arm for women having surgery for breast cancer.

  Recruiting Gangnam Severance Hospital · Seoul · NCT04687956

• Neoadjuvant hormone therapy for extensive ductal carcinoma in situ

  This study is testing if giving hormone therapy before surgery can help women with extensive ductal carcinoma in situ avoid a mastectomy and have better treatment outcomes.

  Recruiting at 7 sites Phase 2 Institut Cancerologie de l'Ouest · Angers and 7 other locations · NCT04666961

• Comparing outcomes of immediate and delayed breast reconstruction after mastectomy

  This study is trying to see how different timing for breast reconstruction after mastectomy affects the appearance, quality of life, and satisfaction of women who have had the surgery.

  Recruiting National Institute of Oncology, Hungary · Budapest · NCT04356235

• Comparing cosmetic results and patient satisfaction of two breast surgery techniques

  This study is trying to see if a newer breast surgery technique gives better cosmetic results and patient satisfaction compared to a traditional method for women under 65 with breast cancer.

  Recruiting National Institute of Oncology, Hungary · Budapest · NCT04345081

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Real-Time, Dye-Free Imaging of Mastectomy Flap Viability

  A new dye-free imaging method tests breast surgery flaps in real time to help doctors see which tissue is healthy after mastectomy.

  NIH research Bioptics Imaging LLC · Lexington, United States · NIH-11407401

• Bionic Breast: Restoring touch and reducing pain after mastectomy

  A small study tests a neural prosthesis to bring back touch and ease chronic pain for women who have had a mastectomy.

  NIH research University of Chicago · Chicago, United States · NIH-11394424

• Bionic breast neuroprosthesis to restore touch and reduce pain after mastectomy

  This trial offers a small implant that senses touch on the reconstructed breast and stimulates chest nerves to bring back feeling and ease chronic pain for women after mastectomy.

  NIH research University of Chicago · Chicago, United States · NIH-11140546

• A device to restore touch sensation and reduce pain after breast surgery

  This study is testing a new device called the Bionic Breast Device that aims to help women who have had a mastectomy by restoring touch sensations and reducing chronic pain, so if you're a breast cancer survivor looking for ways to improve your quality of life, this could be for you!

  NIH research University of Chicago · Chicago, United States · NIH-10894812

• Training to manage pain after breast cancer surgery

  This study is looking at how teaching women with ongoing pain after breast cancer surgery some helpful ways to cope with that pain can make them feel better both emotionally and physically.

  NIH research Duke University · Durham, United States · NIH-10889926

• Improving blood flow and oxygenation assessment in mastectomy skin flaps

  This study is testing a new imaging technique that helps doctors see blood flow and oxygen levels in the skin during breast reconstruction surgery, aiming to make the surgery safer and improve recovery for women after mastectomy.

  NIH research University of Kentucky · Lexington, United States · NIH-10746442

Related topics

Quick answers

How many Mastectomy clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (6 trials), Egypt (5 trials), South Korea (4 trials), Turkey (Türkiye) (3 trials), Hungary (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 4: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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