Pain relief for carpal tunnel syndrome using Dexmedetomidine, Ozone, and Dexamethasone injections

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of a combination of Dexmedetomidine, Ozone, and Dexamethasone injections for pain relief in patients with carpal tunnel syndrome (CTS). CTS is characterized by symptoms related to median nerve compression at the wrist, and current treatments often involve corticosteroid injections. The study will include patients aged 20 to 60 with mild-to-moderate CTS, confirmed by ultrasound and nerve conduction studies. The goal is to determine if this novel combination therapy provides better analgesic outcomes compared to standard treatments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age from 20 to 60 years.
* Both sexes.
* Patients with ultrasonographic evidence of mild-to-moderate carpal tunnel syndrome (CTS).
* Inclusion criteria will include numbness and pain in the median nerve (MN) distribution persisting for minimum of 3 months , nerve conduction studies (NCS) consistent with carpal tunnel syndrome (CTS) as per the American Association of Neuromuscular and Electro diagnostic Medicine (AANEM) guidelines, and an median nerve (MN) cross-sectional area (CSA)at the wrist \>12 mm2 suggesting mild-to-moderate CTS forms.

Exclusion Criteria:

* Patient refusal.
* Patients with severe symptoms and signs of CTS as identified per the American Association of Neuromuscular and Electro diagnostic Medicine (AANEM) guidelines,\[14\] as this is an indication for surgery,
* Patients who show improvement on medical treatment,
* Previous surgical or injectional CTS treatment,
* Pregnancy ,co existence of brachial plexopathy, or thoracic outlet syndrome, polyneuropathy, radiculopathy and peripheral nerve lesion in upper limb.
* Severe cardiovascular disease
* Morbid obese patients (body mass index (BMI) of \>35 kg/m2)
* Infection at site of injection.
* Bleeding diathesis.
* History of thyroid deficiency, uncontrolled diabetes mellitus , rheumatoid arthritis and history of glucose-6-phosphate dehydrogenase (G6PD) deficiency
* History of Ozone or Dexmedetomidine allergy.
* End stage renal and hepatic disease.
* History of inflammatory joint , connective tissue disorders, , burns, any local tissue contractures and history of wrist trauma.
* Patients who will not consent to completing The visual analogue scale (VAS) for pain or nerve conduction study before and after injection.

Where it's running

• Faculty of Medicine
  Tanta, El Gharbia, Egypt Recruiting

Study contacts

• Principal investigator: Mahmoud Elgebaly, Md — Tanta faculty of medicine
• Study coordinator: Mahmoud T Elgebaly, MD
• Email: mahmoud.talaat@med.tanta.edu
• Phone: 00201092415231

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.