Using low doses of dexmedetomidine to treat respiratory failure from fentanyl overdose
Treatment of Fentanyl Overdose-Induced Respiratory Failure by Low-Dose Dexmedetomidine
This study is looking at how a small amount of a brain medication called dexmedetomidine can help people breathe normally again after they've had trouble breathing from a fentanyl overdose.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10701905 on NIH RePORTER |
What this research studies
This research investigates how low doses of dexmedetomidine, a medication that acts on the brain, can help restore normal breathing in patients who have experienced respiratory failure due to fentanyl overdose. The approach involves understanding how fentanyl affects the body's ability to breathe and how dexmedetomidine can counteract these effects. Initially tested in animal models, the research aims to establish effective dosing strategies that can be applied in humans to prevent fatal outcomes from opioid overdoses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced respiratory failure due to fentanyl overdose.
Not a fit: Patients who have not been exposed to opioids or those with respiratory failure from causes other than opioid overdose may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the mortality rate associated with fentanyl overdoses by improving respiratory function.
How similar studies have performed: Previous research has shown promise in using similar approaches to manage opioid overdose, but this specific application of dexmedetomidine is novel.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Haouzi, Philippe a — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Haouzi, Philippe a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.