Dexmedetomidine vs Lignocaine to blunt intubation stress in cardiac surgery
Official title: Comparison of Intravenous Dexmedetomidine and Lignocaine in Reducing Hemodynamic Responses During Laryngoscopy and Endotracheal Intubation In Patients Undergoing Cardiac Surgery at Rawalpindi Institute Of Cardiology- A Randomized Controlled Trial
Run by Rawalpindi Institute of Cardiology · NCT07611890 · Data updated 2026-11-12
This trial tests whether giving dexmedetomidine or lignocaine before airway placement reduces heart and blood pressure changes during intubation in high-risk cardiac surgery patients.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Rawalpindi Institute of Cardiology Academic / other |
| Locations | 1 site (Rawalpindi, Punjab Province) |
| Status | Recruiting |
| Started | May 21, 2026 |
| Main results expected | August 21, 2026 |
| Study ends | August 21, 2026 |
| Registry record updated | May 28, 2026 |
| Trial ID | NCT07611890 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with ASA III–IV status at risk for cardiovascular events undergoing surgery requiring endotracheal intubation.
✕Probably not a fit
Patients without significant hemodynamic responses or with contraindications to either drug may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, single-site study compares two intravenous medicines—dexmedetomidine and lignocaine—given before laryngoscopy and endotracheal intubation in adults with high cardiovascular risk undergoing cardiac surgery. Participants are assigned by computer-generated randomization and use a confidential ID system to protect privacy, with treatment given before airway placement. Vital signs, including mean arterial pressure and heart rate, are recorded at baseline and multiple time points after intubation to see which medication better mitigates hemodynamic responses. Demographic and observational data are collected on a structured form to support analysis. The study aims to determine which option more effectively reduces intubation-related stress in this patient population.
Why it matters
Potential benefit: If successful, the preferred drug could lessen blood pressure and heart rate surges during intubation, potentially improving safety in high-risk cardiac patients.
How similar studies have gone: Previous research in similar settings has explored airway-related hemodynamic control with these agents, showing potential benefits but requiring confirmation in cardiac surgical populations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: American Society of Anesthesiologists (ASA) physical status III-IV. Patients who are at risk of cardiovascular events Exclusion Criteria: 1. Patients with known hypersensitivity to dexmedetomidine and Lignocaine. 2. Patients on medications that could interfere with the study (e.g., beta-blockers, calcium channel blockers). 3. Pregnant or lactating women. 4. Patients with a history of airway anomalies or difficult intubation.
Where it's running
-
Rawalpindi Institute of Cardiology
Rawalpindi, Punjab Province, Pakistan Recruiting
Study contacts
- Study coordinator: Namrah Zujaj, MBBS
- Email: zujajnamrah20@gmail.com
- Phone: +92 305 2636980
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.