Dexmedetomidine to reduce agitation during ventilator weaning
Official title: The Effect of Dexmedetomidine on Agitation During Weaning From Mechanical Ventilation in Critically Ill Patients"
Run by Sohag University · NCT07066605 · Data updated 2026-11-12
This trial will try dexmedetomidine to see if it reduces agitation in adult ICU patients who are ready to be weaned from mechanical ventilation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 19 Years and up |
| Sex | All |
| Enrollment | 62 (estimated) |
| Sponsor | Sohag University Academic / other |
| Locations | 1 site (Sohag) |
| Status | Recruiting |
| Started | June 13, 2025 |
| Main results expected | December 30, 2025 |
| Study ends | December 30, 2025 |
| Registry record updated | July 15, 2025 |
| Trial ID | NCT07066605 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) in the ICU who have been mechanically ventilated for at least 24 hours, are clinically ready for weaning, and demonstrate agitation (RASS ≥ +1) during a spontaneous breathing trial are ideal candidates.
✕Probably not a fit
Patients who are not agitated during weaning, those with unstable heart rate or blood pressure, significant neurologic impairment, known dexmedetomidine allergy, or who are pregnant or breastfeeding are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Critically ill adults on mechanical ventilation who are clinically ready for weaning and show agitation during a spontaneous breathing trial will be assigned to either a dexmedetomidine group or a control group. The study focuses on measuring the level of agitation (RASS) during the weaning process and compares outcomes between the two groups. Key eligibility includes age ≥18, mechanical ventilation ≥24 hours, and RASS ≥ +1 during the trial, while patients with dexmedetomidine hypersensitivity, hemodynamic instability, major neurologic impairment, or pregnancy/lactation are excluded. Outcomes will inform whether using dexmedetomidine during weaning improves patient comfort and the weaning experience.
Why it matters
Potential benefit: If successful, using dexmedetomidine could reduce agitation during ventilator weaning, potentially smoothing extubation and reducing complications and ICU time.
How similar studies have gone: Previous clinical work has shown dexmedetomidine can reduce agitation and aid comfort during mechanical ventilation in some ICU populations, though results vary by protocol and patient mix.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult ICU patients (≥18 years). * On mechanical ventilation ≥24 hours. * Clinically ready for weaning. * Agitation score RASS ≥ +1 during spontaneous breathing trial. * Intubation for at least 4 days: 2 weeks. Exclusion Criteria: * Known hypersensitivity to dexmedetomidine. * Hemodynamic instability (HR \< 50 bpm or MAP \< 60 mmHg). * Neurological impairment affecting level of consciousness. * Pregnancy or lactation.
Where it's running
-
Sohag University Hospital
Sohag, Egypt Recruiting
Study contacts
- Study coordinator: Dalia A Hussein, Resident
- Email: najiza330@gmail.com
- Phone: 01017666214
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.