Esketamine dose levels combined with dexmedetomidine to reduce pain after scoliosis correction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults scheduled for scoliosis correction with pedicle screw fixation who require patient-controlled intravenous analgesia will be assigned to receive different doses of esketamine combined with dexmedetomidine as supplemental postoperative analgesia. The study compares pain scores, opioid consumption, sleep quality, and the occurrence of chronic postsurgical pain over follow-up. Esketamine is used for its NMDA-antagonist antihyperalgesic effects while dexmedetomidine provides sedative and analgesic adjunct effects. Outcomes focus on both short-term analgesia and longer-term pain measured at least three months after surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged ≥18 years and body weight≥40 kg;
* Scheduled to undergo scoliosis correction with pedicle screw fixation;
* Required patient-controlled intravenous analgesia (PCIA) after surgery.

Exclusion Criteria:

* Preoperative sick sinus syndrome, severe sinus bradycardia (heart rate \<50 beats per minute), atrioventricular block grade II or above without pacemaker, congenital heart disease, arrhythmia, or other serious cardiovascular diseases with a New York Heart Association class ≥III;
* Patients with moderate or severe obstructive sleep apnea diagnosed preoperatively or according to the STOP-Bang score;
* History of hyperthyroidism or pheochromocytoma;
* History of schizophrenia, epilepsy, myasthenia gravis;
* Severe liver dysfunction (Child-Pugh grade C), severe renal dysfunction (preoperative dialysis), or American Society of Anaesthesiologists grade ≥IV;
* Barrier in communication;
* Other conditions that were considered unsuitable for study participation.

Where it's running

• Beijing University First Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Dong-Xin Wang, MD, PhD — Peking University First Hospital
• Study coordinator: Dong-Xin Wang, MD, PhD
• Email: wangdongxin@hotmail.com
• Phone: 8610-83572784

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.