Treating delirium after coronary bypass with pregabalin versus dexmedetomidine

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Older patients (≥65) undergoing coronary artery bypass grafting who develop postoperative delirium in a fast-track pathway receive either pregabalin or dexmedetomidine as the intervention. The trial compares the two drugs' effects on the duration and course of postoperative delirium, using clinical assessments of consciousness and cognition during the hospital stay. Eligibility is limited to ASA II–III patients and excludes those with severe organ failure, significant conduction abnormalities, prior major psychiatric disease, or allergies to the study drugs. The interventions are administered in the postoperative period at Tanta University Hospital and outcomes include delirium duration and recovery metrics.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* CABG patients ≥ 65 years of age both genders American Society of Anesthesiologists (ASA) physical status classification II or III planned for fast track developed postoperative delirium (POD).

Exclusion Criteria:

* Patients who had history of psychiatric diseases; inability to communicate;
* previous history of POD; preoperative sick sinus syndrome, allergy/sensitivity to pregabalin or dexmedetomidine, severe bradycardia (heart rate \<50 beat per minute), second-degree or above atrioventricular block without pacemaker; severe hepatic or renal insufficiency.
* Previous cardiac or thoracic surgery, known diagnosis of depression or other major psychiatric diseases, cognitive impairment or inability to cooperate with the study, renal insufficiency, and history of substance abuse.

Where it's running

• Islam Morsy
  Tanta, El-Gharbia Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Islam Morsy, MD
• Email: eslam.morsy@med.tanta.edu.eg
• Phone: 00201093387374

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.