Dexmedetomidine or Clonidine added to spinal anesthesia for cesarean delivery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In cesarean deliveries, spinal anesthesia with bupivacaine and opioids is standard but some patients feel pulling or pressure during the procedure. The trial compares two alpha-2 adrenergic drugs, dexmedetomidine and clonidine, as intrathecal adjuvants to see if they reduce uncomfortable sensations and extend the duration of the block. It is an interventional, phase 4 study conducted at Columbia University focusing on women undergoing cesarean delivery with spinal anesthesia. Outcomes likely include intraoperative comfort, block duration, and postoperative pain, with safety monitoring for known drug effects. Enrollment is limited to eligible pregnant women without major comorbidities or restrictions listed in the criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pregnant women undergoing cesarean delivery with spinal anesthesia

Exclusion Criteria:

* Significant cardiovascular, psychiatric or respiratory disease
* using opioids or with chronic pain syndrome
* Multiple gestation
* BMI \>40 kg/m2
* Quaternary or greater cesarean
* \< 37 weeks gestation
* Non-English or Spanish speaking
* planned vertical skin incision
* planned vertical (classical) uterine incision
* allergy to clonidine, dexmedetomidine or other study drug

Where it's running

• Columbia University Irving Medical Center/NewYork Presbyterian Hospital
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Ruth Landau, MD — Columbia University
• Study coordinator: Richard M Smiley, MD, PhD
• Email: rms7@cumc.columbia.edu
• Phone: 914-584-9531

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.