Using Dexmedetomidine and Esketamine to Reduce Bladder Discomfort from Catheters

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of dexmedetomidine and esketamine on catheter-related bladder discomfort (CRBD) in patients undergoing transurethral urological surgery. It employs a 2x2 factorial design to assess the efficacy of these medications, both individually and in combination, in reducing the incidence of CRBD after surgery. The study aims to improve patient comfort and satisfaction by potentially decreasing the pain and discomfort associated with urinary catheters post-anesthesia. Participants will be monitored for CRBD symptoms and overall recovery outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 years or above;
* Scheduled to undergo transurethral bladder or prostate surgery (including transurethral resection of bladder tumor, transurethral resection of prostate, and transurethral thulium laser prostatectomy) under general anesthesia;
* Required postoperative retention of a three-chamber urinary catheter.

Exclusion Criteria:

* Indwelling urinary catheters or chronic analgesic therapy for ≥1 month before surgery;
* Uncontrolled hypertension before surgery (resting ward systolic pressure \>180 mmHg or diastolic pressure \>110 mmHg);
* Severe bradycardia (heart rate ≤50 beats per minute), sick sinus syndrome, or atrioventricular block of degree II or above without pacemaker, or having myocardial infarction, severe heart insufficiency (New York Heart Association class ≥3), or tachyarrhythmia within a year;
* Preoperative history of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or intracranial hypertension;
* Preoperative history of hyperthyroidism and pheochromocytoma;
* Inability to communicate due to coma, severe dementia, or language barrier before surgery;
* Severe liver dysfunction (Child-Pugh grade C), severe renal dysfunction (receiving dialysis before surgery), or Amercian Society of Anesthesiologists classification ≥IV;
* Scheduled admission to the intensive care unit with endotracheal intubation after surgery;
* Other conditions that are considered unsuitable for study participation.

Where it's running

• Peking University First Hospital
  Beijing, Beijing Municipality, China Recruiting
• Peking University Shenzhen Hospital
  Shenzhen, Guangdong, China Recruiting

Study contacts

• Principal investigator: Dong-Xin Wang, MD, PhD — Peking University First Hospital
• Study coordinator: Rui Zhang, MD
• Email: zhangrui_bjmu@163.com
• Phone: +8618810662529

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Esketamine dose levels combined with dexmedetomidine to reduce pain after scoliosis correction

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.