Dexamethasone, Dexmedetomidine, or Both After Laparoscopic Gallbladder Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants undergoing elective laparoscopic cholecystectomy are randomly assigned to receive dexamethasone, dexmedetomidine, both drugs, or placebo after anesthesia induction. The impact on postoperative gut function is measured with the I-FFED score. The study compares each active treatment to placebo to see if the drugs improve recovery of gastrointestinal function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* . Age 18-65 years.
* American Society of Anesthesiologists (ASA) physical status I or II.
* Scheduled for elective laparoscopic cholecystectomy surgery under general anesthesia.
* Ability to provide written informed consent

Exclusion Criteria:

* Known allergy or contraindication to any study drug (dexamethasone, dexmedetomidine, or placebo).
* Pre-existing gastrointestinal motility disorders (e.g., gastroparesis, inflammatory bowel disease).
* Chronic use of opioids, steroids, or antiemetics.
* History of severe cardiac disease (e.g., high-grade AV block, severe bradycardia).
* Uncontrolled diabetes mellitus (HbA1c \> 8.0%).
* Emergency surgery or conversion to open surgery.
* Pregnancy or breastfeeding.
* Morbid obesity (BMI \>40).
* Severe hepatic or renal dysfunction.

Where it's running

• Benha University Hospital
  Banhā, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.