IV lidocaine versus IV dexmedetomidine for pain control during sleeve gastrectomy
Official title: Intravenous Lidocaine Infusion Versus Intravenous Dexmedetomidine Infusion During Laparoscopic Sleeve Gastrectomy : the Effect on Recovery Outcomes Variables
Run by Alexandria University · NCT07327905 · Data updated 2026-11-12
It tests whether an IV infusion of lidocaine or dexmedetomidine given during laparoscopic sleeve gastrectomy helps reduce early postoperative pain and the need for opioid pain medicines in adults aged 20–50 with BMI 35–50.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 50 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Alexandria University Academic / other |
| Locations | 1 site (Alexandria) |
| Status | Recruiting |
| Started | December 26, 2025 |
| Main results expected | October 1, 2026 |
| Study ends | November 1, 2026 |
| Registry record updated | January 8, 2026 |
| Trial ID | NCT07327905 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 20–50 years with BMI 35–50 kg/m2, ASA class II–III, scheduled for laparoscopic sleeve gastrectomy and without contraindications to lidocaine or dexmedetomidine would be ideal candidates.
✕Probably not a fit
Patients with cardiac conduction disorders, cardiomyopathy, chronic opioid dependence, allergy to the study drugs, or who are pregnant or breastfeeding are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional comparison gives participants one of two intravenous infusions—lidocaine or dexmedetomidine—around the time of laparoscopic sleeve gastrectomy. Adults aged 20–50 with BMI 35–50 and ASA physical status II–III are enrolled and monitored for pain scores, opioid consumption, sedation, and adverse events in the early postoperative period. The protocol tracks safety issues such as cardiac conduction and hemodynamic stability as well as analgesic and anti-inflammatory effects. Patients with cardiac conduction disorders, cardiomyopathy, chronic opioid use, allergy to study drugs, or pregnancy/breastfeeding are excluded.
Why it matters
Potential benefit: If successful, the approach could give better early pain relief with less opioid use and fewer opioid-related side effects after sleeve gastrectomy.
How similar studies have gone: Both intravenous lidocaine and dexmedetomidine have shown benefit in prior surgical studies for reducing postoperative pain and opioid use, but direct head-to-head data specifically in sleeve gastrectomy are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 20-50 years, both sexes. * American Standards Association (ASA) physical status class II to III. * Body mass index (BMI) 35-50 kg m-². Exclusion Criteria: * Cardiac conduction disorders. * Cardiomyopathy. * Chronic opioid use. * Allergy to the studied medications. * Pregnancy and breastfeeding.
Where it's running
-
Alexandria University
Alexandria, Egypt Recruiting
Study contacts
- Principal investigator: sarah m elgamal, MD — Alexandria University
- Study coordinator: sarah m elgamal, MD
- Email: sarahelgamal1990@yahoo.com
- Phone: 01005496440
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Dexmedetomidine vs magnesium with lidocaine for eye block during DCR surgery
This trial tests whether adding dexmedetomidine or magnesium sulfate to lidocaine for a preemptive peribulbar block can better manage blood pressure and heart rate in adults undergoing DCR surgery under general anesthesia.
-
Lidocaine versus dexmedetomidine during abdominal surgery to protect brain oxygen and reduce delirium in older adults
This trial tests whether giving lidocaine or dexmedetomidine during major abdominal surgery helps keep brain oxygen levels stable and reduces postoperative delirium in people aged 65 and older.
-
Comparing dexmedetomidine and lidocaine for pain management after mastectomy
This study is testing whether dexmedetomidine or lidocaine works better for managing pain after mastectomy surgery in adults aged 18 to 75.
-
15-year outcomes after sleeve gastrectomy in France
This study looks at how people who had sleeve gastrectomy have fared over 15 years to see long-term weight changes and health effects.
-
Mother and baby health after bariatric surgery in pregnancy
This study follows pregnant women who have had bariatric surgery and those who have not to see how nutrition, pregnancy health, and baby outcomes compare.
-
Dexmedetomidine to See if Delirium Drops After Hip Fracture Surgery
This observational study tests whether using dexmedetomidine around hip fracture surgery helps prevent postoperative delirium in adults 65 and older.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.