Using Dexmedetomidine to Reduce Delirium After Awake Brain Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effect of dexmedetomidine on the incidence of postoperative delirium in patients undergoing awake craniotomies. Given that postoperative delirium is a common complication in this high-risk population, the study aims to determine if dexmedetomidine can effectively reduce its occurrence. Patients will receive either dexmedetomidine or a saline solution during their procedure, and their postoperative cognitive function will be monitored. The findings could provide insights into better management strategies for patients undergoing brain surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients undergoing selective awake craniotomies.
* Age ≥18 years.
* Obtain written informed consent.

Exclusion Criteria:

* 1.Preoperative moderate and severe cognitive impairment (Montreal Cognitive Assessment, MoCA\< 18).
* 2.Preoperative psychotropic medication within one year.
* 3.BMI≤18 or ≥30 Kg/ m2
* 4.Pregnant or lactating women.
* 5.History of traumatic brain injury or neurosurgery.
* 6.Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block.
* 7.Severe hepatic or renal dysfunction.

Where it's running

• Beijing Tian Tan Hospital, Capital Medical University
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Yuming Peng, MD,Ph.D — Beijing Tiantan Hospital
• Study coordinator: Yuming Peng, MD,Ph.D
• Email: florapym766@163.com
• Phone: 8610-59976658

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.