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Esketamine clinical trials and research

• 10Clinical trials
• 1NIH research projects
• 1Country

Newest Esketamine clinical trials

All recruiting trials (10)

• Intranasal dexmedetomidine‑esketamine for pain relief after adenoid and tonsil surgery in children

  This trial will test whether giving children aged 3–7 a combined dexmedetomidine and esketamine nasal dose reduces pain after adenoid and tonsil surgery.

  Recruiting Phase 4 Peking University First Hospital · Beijing, Beijing Municipality · NCT07479602

• Dexmedetomidine and esketamine given around surgery to improve recovery after general anesthesia

  This trial will test whether giving dexmedetomidine, esketamine, or both during the perioperative period helps adults recover better after surgery under general anesthesia.

  Recruiting Phase 4 Peking University First Hospital · Beijing, Beijing Municipality · NCT07308756

• Low-dose esketamine with modified ECT for severe adolescent depression

  This trial will test whether adding a low dose of esketamine to modified electroconvulsive therapy helps treat severe depression in adolescents aged 13–17 and whether it is safe.

  Recruiting Early Phase 1 First Affiliated Hospital of Chongqing Medical University · Chongqing and 1 other locations · NCT07247968

• Remimazolam, dexmedetomidine, or esketamine to calm young children before surgery

  This trial will test which of three drugs—remimazolam, dexmedetomidine, or esketamine—best calms children aged 2–5 before adenotonsillectomy and reduces postoperative agitation.

  Recruiting Maternal and Child Health Hospital of Hubei Province · Wuhan, Hubei · NCT07050212

• Combining dexmedetomidine and esketamine to improve sleep after major surgery

  This study is testing whether a mix of two medications, dexmedetomidine and esketamine, can help adults sleep better after major surgery compared to a placebo.

  Recruiting Phase 4 Peking University First Hospital · Beijing · NCT06859892

• Using dexmedetomidine and esketamine for sedation in young children before surgery

  This study tests if a combination of two medications, dexmedetomidine and esketamine, can help young children feel calm and relaxed before surgery.

  Recruiting Phase 4 Second Affiliated Hospital of Wenzhou Medical University · Wenzhou, Zhejiang and 1 other locations · NCT06853431

• Low-dose Esketamine for preventing delirium in elderly patients undergoing surgery

  This study is testing if low-dose Esketamine can help prevent confusion after surgery in older adults aged 65 to 90.

  Recruiting at 3 sites Nanfang Hospital, Southern Medical University · Fuzhou, Fujian and 5 other locations · NCT06817239

• Using low doses of esketamine to improve sleep quality after breast cancer surgery

  This study is testing whether low doses of esketamine can help improve sleep quality for people recovering from breast cancer surgery.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu · NCT06773143

• Using Dexmedetomidine and Esketamine to Reduce Bladder Discomfort from Catheters

  This study is testing if the combination of two medications, dexmedetomidine and esketamine, can help reduce bladder discomfort caused by catheters in patients having urological surgery.

  Recruiting at 2 sites Phase 4 Peking University First Hospital · Beijing, Beijing Municipality and 1 other locations · NCT06399185

• Esketamine dose levels combined with dexmedetomidine to reduce pain after scoliosis correction

  This study will test whether different doses of esketamine given with dexmedetomidine and opioids can reduce immediate postoperative pain and lower the chance of chronic postsurgical pain in adults having scoliosis correction.

  Recruiting Phase 4 Peking University First Hospital · Beijing, Beijing Municipality · NCT06087510

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Combining esketamine with cognitive behavioral therapy for hospitalized patients with depression and suicidal thoughts

  This study is looking at how well combining a fast-acting depression medication called esketamine with talk therapy can help people who are in the hospital because they are feeling suicidal, aiming to see if this mix can improve their mood and keep them safe after they leave.

  NIH research Yale University · New Haven, United States · NIH-10688291

Related topics

Quick answers

How many Esketamine clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in China. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 6, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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