Condition

General Anesthesia clinical trials and research

• 26Clinical trials
• 19NIH research projects
• 1New in 30 days
• 13Countries

Newest General Anesthesia clinical trials

All recruiting trials (26)

• Frontal EEG Changes During Anesthesia in People With Obesity vs. Normal Weight

  This study tests whether frontal brain activity patterns during anesthesia differ between adults with obesity and those of normal weight.

  Recruiting Duzce University · Düzce, Düzce · NCT07877090

• Remimazolam versus Midazolam for anesthesia induction in older adults

  This observational study compares remimazolam and midazolam when inducing anesthesia in people aged 65 and older undergoing elective non-cardiac surgery to see which provides better stability and safety.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07746505

• Dexmedetomidine vs magnesium with lidocaine for eye block during DCR surgery

  This trial tests whether adding dexmedetomidine or magnesium sulfate to lidocaine for a preemptive peribulbar block can better manage blood pressure and heart rate in adults undergoing DCR surgery under general anesthesia.

  Recruiting Cairo University · Cairo · NCT07675616

• Hyperangulated vs. Macintosh blades for obstetric intubation

  This study tests whether a hyperangulated blade or a Macintosh-style blade helps obstetric patients get an endotracheal tube placement more safely during cesarean deliveries under general anesthesia.

  Recruiting Samuel Lunenfeld Research Institute, Mount Sinai Hospital · Toronto, Ontario · NCT07667010

• Hyperangulated vs. Macintosh blades for obstetric intubation

  This study tests whether a hyperangulated blade or a Macintosh-style blade helps obstetric patients get an endotracheal tube placement more safely during cesarean deliveries under general anesthesia.

  Recruiting Samuel Lunenfeld Research Institute, Mount Sinai Hospital · Toronto, Ontario · NCT07667010

• Pain monitoring with ANI during rapid sequence induction

  This study tests whether the Analgesia Nociception Index (ANI) can measure pain during rapid sequence induction in adults undergoing tracheal intubation.

  Recruiting Centre Hospitalier Princesse Grace · Monaco · NCT07588165

• Sphenopalatine ganglion block to improve the surgical field during endoscopic pituitary removal

  This trial will try an ultrasound-guided sphenopalatine ganglion block with bupivacaine and dexamethasone alongside general anesthesia to see if it improves the surgeon's view and reduces postoperative pain for adults aged 21–60 having endoscopic trans-nasal pituitary surgery.

  Recruiting Cairo University · Cairo · NCT07569952

• Sublingual caffeine to shorten recovery and reduce agitation after general anesthesia in older adults

  This trial will test whether a single dose of sublingual caffeine helps people aged 65 and older wake up faster and have less postoperative agitation after elective eye surgery under general anesthesia.

  Recruiting Cairo University · Cairo · NCT07536568

• Video laryngoscopy versus direct laryngoscopy for initial tracheal intubation in children

  This trial tests whether using a video laryngoscope on the first try helps doctors successfully place a breathing tube in children undergoing surgery more often than a direct laryngoscope.

  Recruiting Hospital Clinico Universitario de Santiago · Santiago de Compostela, A CORUÑA · NCT07495436

• Pre-op ultrasound of the IVC and aorta to predict blood pressure drops after anesthesia

  We will see if simple pre-op ultrasound measurements of the IVC collapsibility and the caval–aorta index can predict which adults having elective craniotomy will have a drop in blood pressure when general anesthesia is started.

  Recruiting Ain Shams University · Cairo · NCT07399093

• Dexmedetomidine and esketamine given around surgery to improve recovery after general anesthesia

  This trial will test whether giving dexmedetomidine, esketamine, or both during the perioperative period helps adults recover better after surgery under general anesthesia.

  Recruiting Phase 4 Peking University First Hospital · Beijing, Beijing Municipality · NCT07308756

• Breath sound monitoring during general anesthesia

  This project will test whether continuous electronic stethoscope monitoring during general anesthesia can help detect abnormal breathing and support safer respiratory care for adults having elective surgery.

  Recruiting Taipei Veterans General Hospital, Taiwan · Taipei · NCT07280546

• Anesthesia choice for mechanical thrombectomy in ischemic stroke

  In people with severe ischemic stroke due to a large vessel blockage who need mechanical thrombectomy, this study tests whether general anesthesia works better than procedural sedation for improving daily function 3 months later.

  Recruiting at 7 sites University Hospital, Clermont-Ferrand · Angers and 15 other locations · NCT07235514

• Safer muscle relaxant and reversal choice during anesthesia for people with chronic kidney disease

  This trial will try to see if using cisatracurium with neostigmine leads to fewer breathing problems after surgery than using rocuronium with sugammadex in adults who have chronic kidney disease.

  Recruiting Phase 4 The University of Texas Medical Branch, Galveston · Galveston, Texas · NCT07203287

• Impact of Operating Room Noise on BIS and Hemodynamics During General Anesthesia

  This study tests whether higher operating room noise affects BIS readings and blood pressure and heart rate in adults having general anesthesia.

  Recruiting Başakşehir Çam & Sakura City Hospital · Başakşehir, Istanbul · NCT07194707

• Validate the MASCAN score for predicting difficult facemask ventilation

  This study will see if the MASCAN score can predict difficult facemask ventilation in adults having general anesthesia and whether factors like timing of muscle relaxants, manual versus controlled ventilation, and capnography readings change its accuracy.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg, Free and Hanseatic City of Hamburg · NCT07114549

• General versus spinal anesthesia with local numbing for buccal mucosal graft urethroplasty

  This project will see if spinal anesthesia plus local numbing causes less mouth and overall postoperative pain than general anesthesia for adult men having urethroplasty with a buccal (cheek) graft.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07074730

• Comparing awake thoracic epidural anesthesia to general anesthesia for thoracotomy

  This study is testing whether awake thoracic epidural anesthesia can help people having thoracotomy surgery manage pain better than general anesthesia.

  Recruiting Cairo University · Cairo · NCT06930183

• Comparing dexmedetomidine and lidocaine for pain management after mastectomy

  This study is testing whether dexmedetomidine or lidocaine works better for managing pain after mastectomy surgery in adults aged 18 to 75.

  Recruiting Cairo University · Cairo · NCT06910644

• Investigating veinous lactate levels to predict complications after surgery in infants

  This study is testing if measuring lactate levels in the blood after surgery can help predict complications in infants aged 0-1 year.

  Recruiting Hôpital Armand Trousseau · Paris · NCT06909227

• Using high-flow nasal oxygen for preoxygenation in emergency surgery patients with full stomachs

  This study is testing if high-flow nasal oxygen can help emergency surgery patients with full stomachs breathe better before anesthesia compared to using a regular face mask.

  Recruiting Vietnam Military Medical University · Viet Tri, Phu Tho · NCT06879600

• Comparing airway devices in children undergoing orthopedic surgery

  This study is testing which of two airway devices, Ambu AuraGain or i-gel, works better and safer for kids having orthopedic surgery under general anesthesia.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT06853756

• Comparing two airway devices for minor urological procedures under general anesthesia

  This study is testing which of two airway devices, the iGel or the Protector, works better and safer for adults undergoing minor urological procedures with general anesthesia.

  Recruiting Sismanoglio General Hospital · Athens and 1 other locations · NCT06825910

• Scale to measure mouth and throat symptoms after general anesthesia

  This research will test a short questionnaire to measure mouth and throat symptoms in adults who had general anesthesia.

  Recruiting Nuh Naci Yazgan University · Kayseri, Türkiye · NCT06755853

• Using Virtual Reality and Music to Reduce Anxiety in Gynecological Surgery Patients

  This study is testing whether using virtual reality and music can help reduce anxiety and improve sleep for people aged 20 to 65 who are having gynecological surgery.

  Recruiting Yonsei University · Seoul · NCT06728163

• Registry for general anesthesia use in cesarean deliveries

  This study looks at how general anesthesia is used during cesarean deliveries to see what factors affect its use and how it impacts mothers and babies.

  Recruiting at 34 sites Yale University · Little Rock, Arkansas and 34 other locations · NCT06030063

NIH-funded research (19)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Elderly-friendly, interpretable brain-monitoring to guide anesthesia with a FDA-cleared EEG device

  A small FDA-cleared brain-monitoring system and new, easy-to-understand brain-state markers will help tailor anesthesia doses for older adults, especially those with Alzheimer’s disease and related dementias.

  NIH research Pascall Systems, Incorporated · Boston, UNITED STATES · NIH-11419855

• How common anesthetics affect Alzheimer-related brain changes in men and women

  This project looks at whether common anesthetics cause Alzheimer-related brain changes differently in men and women and whether sex hormones might protect older adults who need surgery.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11396753

• Understanding how people wake up from general anesthesia

  This grant studies why people wake up from anesthesia and what happens in the brain when they emerge, aiming to reduce confusion and agitation after surgery.

  NIH research University of Washington · Seattle, United States · NIH-11376537

• Personalized brain-monitoring system to guide anesthesia in older adults

  This project is building a user-friendly EEG system to help tailor propofol anesthesia for older adults, including people with Alzheimer's and related dementias.

  NIH research Pascall Systems, Incorporated · Boston, UNITED STATES · NIH-11375757

• How different anesthesia drugs and sleep affect brain cells during slow waves

  This project tests how various anesthesia drugs and natural sleep cause slow brain waves and whether they involve the same brain circuits in people like you.

  NIH research Brigham Young University · Provo, United States · NIH-11336933

• Active monitoring to guide pain and nerve block care during surgery and recovery

  A new method using brain-wave signals could help doctors tailor pain relief during surgery and after, improving comfort and reducing opioid use.

  NIH research Pascall Systems, Incorporated · Boston, UNITED STATES · NIH-11314661

• Investigating how different anesthetics and sleep affect brain wave patterns.

  This study is looking at how different types of anesthesia affect brain activity during sleep and anesthesia, using tiny animals to help us learn more about how our brains work when we're unconscious, which could improve how we use anesthesia in people.

  NIH research Brigham Young University · Provo, United States · NIH-11293098

• A device to detect hidden pain signals during and after surgery

  This project uses a scalp sensor to find pain-related brain signals so anesthesiologists can better manage pain during and after surgery.

  NIH research Pascall Systems, Incorporated · Boston, UNITED STATES · NIH-11176849

• Creating new technologies to better manage pain during and after surgery

  This study is testing new ways to help doctors better manage pain during and after surgery, especially for patients getting regional anesthesia, so they can provide more personalized care and help prevent long-term pain and reliance on pain medications.

  NIH research Pascall Systems, Incorporated · Boston, UNITED STATES · NIH-11160369

• Understanding how we wake up from general anesthesia

  This research explores the brain's processes when waking up from general anesthesia, aiming to make the experience smoother for patients.

  NIH research University of Washington · Seattle, United States · NIH-11141217

• Understanding sleep and memory after surgery and anesthesia

  This research explores how sleep affects memory and thinking abilities in older adults after they have surgery and anesthesia.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11097233

• Understanding how patients wake up from general anesthesia

  This study is looking at how certain proteins in the brain help people wake up smoothly from general anesthesia, with the goal of making recovery easier and reducing confusion or agitation after surgery.

  NIH research University of Washington · Seattle, United States · NIH-11090283

• New technologies to monitor pain and opioid use during surgery

  This study is working on new tools to help doctors better understand and manage pain during surgery, so they can give just the right amount of pain relief and reduce the chances of long-term reliance on opioids.

  NIH research Pascall Systems, Incorporated · Boston, UNITED STATES · NIH-11012570

• Improving anesthesia management for elderly patients with Alzheimer's and related dementias

  This study is looking to make general anesthesia safer and more effective for older adults, especially those with Alzheimer's and similar conditions, by creating a smart monitoring system that helps doctors give just the right amount of anesthesia during surgery.

  NIH research Pascall Systems, Incorporated · Boston, UNITED STATES · NIH-11008566

• Understanding how patients wake up from general anesthesia

  This study is looking at how certain proteins in the brain help people wake up smoothly from anesthesia, so we can find better ways to help patients avoid confusion or agitation when they come out of it.

  NIH research University of Washington · Seattle, United States · NIH-10887628

• Investigating the effects of anesthesia on Alzheimer's disease development

  This study is looking at how different types of anesthesia might affect the progression of Alzheimer's disease in patients, especially considering whether men and women are impacted differently, to help improve surgical outcomes for those living with the condition.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10875775

• Creating new technologies to better manage pain and opioid use during surgery

  This study is looking at new ways to track how much pain you feel during surgery and how much medicine you need to feel better, with the hope of making sure you get just the right amount of pain relief and reducing the chances of needing opioids later on.

  NIH research Pascall Systems, Incorporated · Boston, UNITED STATES · NIH-10875550

• Comparing spinal anesthesia without opioids to general anesthesia in infants

  This study is looking at how using a special type of spinal anesthesia instead of regular general anesthesia can help babies avoid opioids during surgery, with the hope of keeping them safer and supporting their healthy development.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-10818500

• The effects of general anesthesia on brain development in young children

  This study is looking at how having general anesthesia as a young child might affect brain development and thinking skills later on, by comparing teens who had anesthesia with those who didn't, to see if there are any differences in their brain structure and abilities.

  NIH research University of Iowa · Iowa City, United States · NIH-10641652

Related topics

Quick answers

How many General Anesthesia clinical trials are recruiting right now?

26, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in Egypt (8 trials), Canada (3 trials), Turkey (Türkiye) (3 trials), United States (2 trials), China (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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