Effects of dexmedetomidine and esketamine on sleep after cardiac surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates how dexmedetomidine and esketamine influence postoperative sleep disturbances in patients undergoing cardiac surgery. Participants will receive either dexmedetomidine, esketamine, or a saline control during surgery, followed by assessments of their sleep quality on the first and third postoperative days. The study aims to determine which of the two medications is more effective in preventing sleep issues after surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. ASA class II-III, NYHA class I-III, EF ≥ 50%
2. Intended to perform cardiac surgery under extracorporeal circulation

Exclusion Criteria:

1. Patients undergoing second heart surgery
2. Patients with mental retardation, deafness, or other conditions that interfere with normal communication
3. Previous neurological or psychiatric disorders
4. Patients with a history of sleep disorders
5. Alcoholics, drug addicts, or psychotropic substance abusers
6. Significant hepatic or renal dysfunction affecting drug metabolism
7. Contraindication to the use of dexmedetomidine or esketamine.

Where it's running

• Nanjing First Hospital
  Nanjing, Jiangsu, China Recruiting
• Nanjing First Hospital，Nanjing Medical University
  Nanjing, Jiangsu, China Not yet recruiting

Study contacts

• Study coordinator: Kuang xueyi
• Email: kxy809707496@126.com
• Phone: 86+18651908072

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.