Evaluating comprehensive molecular testing for advanced cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The BEGIN Study by BostonGene and Exigent aims to assess the efficacy and feasibility of comprehensive molecular testing in patients with advanced cancers such as breast cancer, non-small cell lung cancer, melanoma, and sarcoma. Utilizing the BostonGene Tumor Portrait test, the study will identify actionable genomic findings and evaluate their impact on treatment decisions and patient outcomes. Over two years, four cohorts of 100 patients each will be monitored to determine the frequency of molecularly matched therapies and patient enrollment in clinical trials based on test results. The study seeks to demonstrate the clinical utility of genomic testing in guiding therapy in community settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients must have a confirmed malignancy of:

Locally recurrent, unresectable, or metastatic breast cancer or; Unresectable stage III or metastatic non-small cell lung cancer or; Unresectable or metastatic melanoma or; Locally advanced or metastatic l sarcoma.

* Life expectancy \> 3 months as per the treating physician
* Willingness to provide informed consent
* Living in the United States at time of enrollment
* Agree to participate in genomic and molecular profiling

Exclusion Criteria:

* not meeting the inclusion criteria

Where it's running

• Highlands Oncology Group
  Rogers, Arkansas, United States Recruiting
• Stockton Hematology Oncology Medical Group
  Stockton, California, United States Recruiting
• Fort Wayne Medical Oncology and Hematology
  Fort Wayne, Indiana, United States Recruiting
• New Mexico Cancer Center
  Albuquerque, New Mexico, United States Recruiting
• Oklahoma Cancer Specialists and Research Institute
  Tulsa, Oklahoma, United States Recruiting
• Oncology Consultants
  Houston, Texas, United States Recruiting

Study contacts

• Study coordinator: Rheanna Carter, MBA
• Email: rheanna.carter@bostongene.com
• Phone: 650-773-0771

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.