Pain patterns and opioid use in adolescent and young adult sarcoma survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational pilot that asks eligible sarcoma survivors to complete baseline questionnaires, daily ecological momentary assessments (EMAs) via smartphone for three months, and a brief interview about the experience. The EMA protocol records real-time pain intensity, opioid use, and contextual factors multiple times per day. The study aims to measure feasibility and acceptability, quantify day-to-day variability in pain and opioid use, and explore links between biopsychosocial factors (for example, pain beliefs and worry) and pain/opioid outcomes. Findings will inform whether this approach can be used in larger studies or clinical monitoring.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All genders between the ages of 12-24 (inclusive) at sarcoma diagnosis.
* Any age \< 70 at the time of study enrollment.
* No evidence of disease and/or enrolled in survivorship care.
* Clinically meaningful pain related to disease or its treatments at baseline (defined as 3 or greater on a 0-10 Numerical Rating Scale).
* Willing to attend the baseline appointment in person.
* Access to internet-capable smartphone.
* Access to internet on an occasional basis.
* Willing and able to complete Ecological Momentary Assessments (EMAs) on internet-capable smartphone for a 3-month period after enrollment.
* Ability to understand and provide informed consent/assent.

Exclusion Criteria:

* \* Currently receiving active cancer-directed therapy.

  * Unable to read or fluently speak English.
  * Determined by clinical staff to have preexisting or cancer-associated cognitive impairment that could interfere with study participation.
  * Acutely suicidal (e.g. intent or plan) or, with unstable medical or psychiatric condition verified by licensed study staff.
  * Characteristics related to inability to complete the study protocol.

Where it's running

• Roswell Park Comprehensive Cancer Center
  Buffalo, New York, United States Recruiting

Study contacts

• Principal investigator: Andrew Rogers — Roswell Park
• Study coordinator: Andrew Rogers
• Email: Andrew.Rogers@roswellpark.org
• Phone: 1-800-767-9355

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• MIGHTY: CAR T cells targeting B7-H3 for pediatric, teen, and young adult sarcoma

  This Phase 1 trial tests autologous hBRCA84D CAR T cells in kids, teens, and young adults (1–24) with relapsed or refractory RMS, ES, or DSRCT to see if the therapy is feasible and safe.

  Recruiting at 2 sites Phase 1 University College, London · London and 1 other locations · NCT07751380

• Lifileucel (Tumor-infiltrating lymphocytes) for advanced soft tissue sarcoma

  This study tests lifileucel, a cell therapy made from a patient’s own tumor cells, in adults with unresectable or metastatic soft tissue sarcoma who have had prior treatments to see if it helps shrink tumors and improve outcomes.

  Recruiting at 2 sites Phase 2 Iovance Biotherapeutics, Inc. · Tampa, Florida and 1 other locations · NCT07741877

• Domatinostat with Sirolimus for relapsed or refractory sarcoma and osteosarcoma

  This study tests whether the cancer drugs domatinostat and sirolimus together can help adolescents and adults whose sarcoma or osteosarcoma has come back or stopped responding to standard therapy.

  Recruiting at 2 sites Phase 1/2 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida and 3 other locations · NCT07725380

• Clonal Hematopoiesis Effects with Chemo and Radiation in Solid Cancers

  This study tests whether clonal hematopoiesis affects outcomes for adults with solid cancers who are receiving chemotherapy or radiation.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT07675967

• AYA Sarcoma Survivors: Personalized Exercise Program Pilot

  This pilot tests a personalized 12-week exercise program for adolescents and young adults with sarcoma to see if a triage tool can connect them with the right rehabilitation and exercise services.

  Recruiting at 3 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 2 other locations · NCT07662239

• Fluorescence-guided surgery to reduce unexpected positive margins in high-grade sarcoma

  This phase II trial tests whether adding fluorescence-guided surgery with indocyanine green can lower unexpected positive margins in patients with high-grade sarcoma compared to standard surgery.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California · NCT07650656

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.