Investigating cognitive impairment in young cancer patients during and after chemotherapy
Official title: A Multidisciplinary Neuroscience Approach to Investigate Cognitive Impairment in Young Patients With Cancer Prospectively
Run by Copenhagen University Hospital, Rigshospitalet · NCT05840575 · Data updated 2026-11-12
This study is testing how chemotherapy affects memory and attention in children and young adults with cancer to better understand their cognitive challenges during and after treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 7 Years to 29 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Copenhagen University Hospital, Rigshospitalet Academic / other |
| Drugs / interventions | chemotherapy, methotrexate |
| Locations | 1 site (Copenhagen) |
| Status | Recruiting |
| Started | March 1, 2022 |
| Main results expected | March 1, 2027 |
| Study ends | March 1, 2027 |
| Registry record updated | May 3, 2023 |
| Trial ID | NCT05840575 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are newly diagnosed patients aged 7-29 years with non-CNS cancer who will undergo chemotherapy.
✕Probably not a fit
Patients with severe intellectual disabilities, mental health disorders, or those who have had previous chemotherapy or radiotherapy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The MyBrain study examines the cognitive function of children, adolescents, and young adults undergoing chemotherapy for cancer. It assesses cognitive skills such as memory and attention, brain electrical activity through electroencephalograms, and biological markers related to brain function. The study aims to understand the patterns of cognitive impairment associated with chemotherapy and how these may affect patients over time. By comparing patients with matched controls, the research seeks to provide insights into the cognitive challenges faced by young cancer patients.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cognitive impairment in young cancer patients, enhancing their quality of life.
How similar studies have gone: Other studies have indicated cognitive impairment in cancer patients, but this specific approach focusing on young patients during chemotherapy is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who are newly diagnosed with a non-CNS cancer and will undergo chemotherapy at University Hospital Copenhagen, Rigshospitalet. * At the age of 7-29 years at diagnosis * Each patient is matched (1:1) with a control participant within 24 months of age. The controls are recruited from the patient's own social circle and can be a friend, partner, or close family (sibling or cousin). Exclusion Criteria: * Unable to speak and understand Danish * Severe intellectual disability or mental health disorder that hinders participation * Brain metastases, * Terminal illness * Have had a previous chemotherapy or radiotherapy treatment
Where it's running
-
Rigshospitalet
Copenhagen, Denmark Recruiting
Study contacts
- Study coordinator: Lisa L Hjalgrim, PhD, MD
- Email: lisa.lyngsie.hjalgrim@regionh.dk
- Phone: +4535450962
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.