Molecular testing for personalized cancer therapy at MD Anderson

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study conducts standardized testing of tumor tissue samples to identify genetic mutations in patients with various types of cancer, including glioma, melanoma, and sarcoma. The primary goal is to assist in personalized cancer therapy by establishing a database of mutations and alterations in cancer-related genes. Researchers aim to determine the frequency of these mutations and their impact on treatment responses, ultimately helping to match patients with relevant clinical trials. The study also explores the feasibility of identifying actionable targets for targeted therapy based on genetic profiling.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients must have histologically, radiographic, or cytologically documented cancer, suspected glioma, sarcoma, melanoma or hematologic cancer. Patients with benign tumors may also be consented at the discretion of the attending physician if molecular profiling is felt to have potential clinical implications.
* Patients must have the ability to understand and the willingness to sign a written informed consent document
* Patients may be consented without confirming the amount and quality of archival diagnostic or residual tissue available. However, research testing will only be performed on patients who have sufficient archived diagnostic tissue or residual tissue banked in one of the authorized tissue banks at MD Anderson available to proceed with testing. The extent of testing may be modified based on amount of tissue available. If any new tissue acquisition including a biopsy and/or surgical resection etc. is being ordered for clinical care or another research study, or an operation is being performed testing can be ordered on that sample
* Circulating cell-free deoxyribonucleic acid (cfDNA) Cohort: Circulating cell-free DNA next generation sequencing (NGS) testing will be performed with the Clinical Laboratory Improvement Act (CLIA)-certified Guardant360 panel (or equivalent) for select patients. This particular cohort of research collaboration will be supported by Guardant Health, Inc. at no charge to MD Anderson. Patients who are being considered for enrollment into clinical trials in the next 2 lines of therapy may be enrolled. Selected patients may have cfDNA, circulating RNA /exosome/circulating tumor cell testing approaches performed on alternate platforms (eg Foundation ACT)

Where it's running

• M D Anderson Cancer Center
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Funda Meric-Bernstam — M.D. Anderson Cancer Center
• Study coordinator: Funda Meric-Bernstam, MD
• Email: fmeric@mdanderson.org
• Phone: 713-792-6940

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.