Creating immune organoids to study pediatric cancers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to engineer immune organoids from tissues of pediatric patients using induced-pluripotent stem cells (iPSC). By utilizing skin biopsies, fresh tumor samples, blood samples, healthy tissue, and cerebrospinal fluid, the research seeks to better understand the immune response in various pediatric cancers, including brain tumors, kidney tumors, neuroblastoma, and sarcomas. The approach focuses on leveraging patient-derived materials to create organoids that can mimic the tumor environment and immune interactions. This innovative methodology may provide insights into treatment responses and disease mechanisms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age at diagnosis ≤ 25 years except for patients with malignant gliomas and renal tumors for whom no upper age limit is applied
* Medical suspicion or diagnosis of one of the following diseases, regardless of stage:
* Brain tumors
* Renal tumors
* Neuroblastoma
* Sarcomas
* Adult patient or parents or guardians should understand, sign and date the appropriate written informed consent from prior to any protocol-specific procedures performed. Patient should be able and willing to comply with study visits and procedures as per protocol.
* Affiliated to a social security system or beneficiary of the same.

Exclusion Criteria:

* Any histology not mentioned in the inclusion criteria
* Adult patient or parents/guardians incapable/incapable of giving its/their consent
* Patients deprived of their liberty by a judicial or administrative decision

Where it's running

• Gustave Roussy
  Villejuif, France Recruiting
• Hopital Necker
  Paris, Île-de-France Region, France Recruiting

Study contacts

• Study coordinator: Claudia PASQUALINI, MD
• Email: claudia.pasqualini@gustaveroussy.fr
• Phone: +33 (0)1 42 11 55 31

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.