MD Anderson Sarcoma SPORE: advanced immunotherapy and targeted treatments for sarcoma across ages
Official title: MD Anderson Sarcoma SPORE
Funded at University of Tx Md Anderson Can Ctr · NIH-11397753 · Data updated 2026-11-12
A multi-institutional effort is testing immune-based and targeted therapies to reduce illness and death from sarcoma for patients of all ages.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 19, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $1,813,200 |
| NIH project number | 5P50CA302482-02 |
| Project ID | NIH-11397753 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults and youths with sarcoma, including chordoma and osteosarcoma, who may participate in clinical trials or related studies.
✕Less likely to help
Some patients may not respond to the specific therapies or may have constraints that prevent participation in trials.
What this research studies
This grant supports translational research at MD Anderson to develop innovative immunotherapies and targeted treatments for sarcoma. It brings together clinicians, scientists, and data experts to address pediatric, adolescent-young adult, and adult patients with sarcoma. Project 2 focuses on an adoptive T cell therapy for chordoma, using a well-validated Brachyury epitope to guide a clinical trial. Project 3 aims to improve antibody-drug conjugates that target osteosarcoma-specific proteins to enhance tumor killing. The work emphasizes cross-age collaboration and rigorous preclinical-to-clinical translation. The goal is to shorten the path from discovery to effective treatments that reduce morbidity and mortality in sarcoma patients.
Why it matters
Potential benefit: Could lead to new, more effective immunotherapies and targeted drugs for sarcoma patients of any age.
How similar studies have gone: Previous studies in adoptive cell therapy and antibody-drug conjugates have shown promise in sarcomas, supporting continued development.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Gorlick, Richard G. — University of Tx Md Anderson Can Ctr
- Study coordinator: Gorlick, Richard G.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.