Understanding how USP1 helps Ewing sarcoma cells bypass replication stress
Official title: Mechanisms underlying USP1-mediated bypass of EWS-FLI1 oncogene-induced replication stress in Ewing sarcoma
Funded at University of Nebraska Medical Center · NIH-11362462 · Data updated 2026-11-12
Researchers are studying how a protein called USP1 lets Ewing sarcoma cells survive stress that would normally stop cancer growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | August 5, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $351,131 |
| NIH project number | 5R01CA263504-05 |
| Project ID | NIH-11362462 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with Ewing sarcoma or related bone cancers, whose tumors overexpress USP1 or experience replication stress, may benefit from future therapies arising from this work.
✕Less likely to help
Patients without tumors driven by EWS-FLI1–related replication stress or without USP1 overexpression may see limited direct benefit.
What this research studies
This project looks at why cancer cells with the EWS-FLI1 gene fusion can dodge the usual DNA damage responses. By focusing on USP1’s role in regulating replication stress, the study aims to uncover targets for new therapies. The work uses cancer cell models and experiments to reveal how bypassing stress responses contributes to tumor progression. Findings could point to novel treatments that restore the cell’s natural checks on growth.
Why it matters
Potential benefit: If successful, the research could lead to new therapies that make Ewing sarcoma cells more vulnerable to treatment by reactivating replication stress responses.
How similar studies have gone: Previous studies have linked replication stress pathways to cancer survival; this project builds on that knowledge to identify specific mechanisms in Ewing sarcoma.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Ghosal, Gargi — University of Nebraska Medical Center
- Study coordinator: Ghosal, Gargi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.