Multimodal approach to understand CIC::DUX4 sarcoma in mice
Official title: Multimodal approach to decipher CIC::DUX4 sarcoma
Funded at University of Minnesota · NIH-11447311 · Data updated 2026-11-12
A study using mouse models of CIC::DUX4 sarcoma to uncover how this aggressive cancer starts, grows, and responds to treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 21, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $548,075 |
| NIH project number | 1R01CA308971-01A1 |
| Project ID | NIH-11447311 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with CIC::DUX4 sarcoma or similar aggressive CDS may benefit from advances in modeling and therapy development.
✕Less likely to help
The study is preclinical and does not involve treating patients directly.
What this research studies
Researchers created CIC::DUX4-inducible mouse models that mimic human CDS tumors to study tumor initiation, progression, and interactions with the immune environment. They will define which tissues can host CIC::DUX4-driven tumors, map the molecular pathways driving growth and immune evasion, and test targeted therapies. The work aims to establish reliable CDS mouse models and generate data to guide future human trials and treatment strategies.
Why it matters
Potential benefit: This work could lead to better understanding of CDS and faster development of effective therapies for patients with this rare cancer.
How similar studies have gone: Preclinical CDS models have helped uncover growth pathways and immune interactions, but robust in vivo CDS models are still needed.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Bosnakovski, Darko — University of Minnesota
- Study coordinator: Bosnakovski, Darko
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.