SPORE in Soft Tissue Sarcoma: targeted therapies and biomarkers to help patients
Official title: SPORE in Soft Tissue Sarcoma
Funded at Sloan-Kettering Inst Can Research · NIH-11419123 · Data updated 2026-11-12
A big research effort at a major cancer center aims to develop targeted treatments and biomarkers to improve outcomes for people with soft tissue sarcoma.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2018 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $2,452,231 |
| NIH project number | 5P50CA217694-08 |
| Project ID | NIH-11419123 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults and children with soft tissue sarcoma who could benefit from targeted therapies or biomarker-guided treatment.
✕Less likely to help
Patients without actionable molecular targets or those unsuitable for targeted/immune therapies may see limited direct benefit.
What this research studies
This project brings together researchers to study the molecular drivers of soft tissue sarcoma and identify targets for new therapies. It uses a large, long-running clinicopathologic database, sarcoma tissue and blood banks, and patient-derived models to test ideas and predict which treatments might work. The work spans basic biology, translational studies, and plans to guide clinical trials for adults and children. If successful, it could lead to more precise, effective therapies and better biomarker-guided care for sarcoma patients.
Why it matters
Potential benefit: If successful, patients with soft tissue sarcoma could receive more effective, tailored treatments and better prognostic information.
How similar studies have gone: Previous research in soft tissue sarcoma has identified targets and biomarkers, with ongoing work translating these findings to clinical trials.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Singer, Samuel — Sloan-Kettering Inst Can Research
- Study coordinator: Singer, Samuel
Related research
Other NIH-funded projects on the same topics.
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Ultra-steerable ultrasound therapy for soft tissue sarcoma
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This project combines an antibody that soaks up a tumor-made immune blocker with natural killer (NK) cell therapy to help dogs and, eventually, people with soft tissue sarcoma fight their tumors.
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Targeted treatments for soft tissue sarcoma
This project is testing targeted drugs and immunotherapies for people with soft tissue sarcoma, including adults and children.
-
Enhancing cancer treatment using natural killer cells in dogs with soft tissue sarcoma
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Non-invasive treatment for soft tissue sarcoma using ultrasound technology
This study is testing a new ultrasound treatment that gently breaks down tough tumors in soft tissues, making it easier for patients with hard-to-reach sarcomas to manage their cancer without needing surgery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.