Collecting and storing samples from children and adults with common childhood cancers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to develop a comprehensive tissue repository for pediatric solid tumors and related biological studies. It involves collecting and storing blood, serum, tissue, urine, or tumor samples from individuals diagnosed with common childhood cancers, including sarcoma, neuroblastoma, and others. The study will also include systematic molecular, genomic, and proteomic profiling of the collected specimens to enhance understanding of cancer biology and improve treatment options. Participants may include patients of any age with a cancer diagnosis, their biological relatives, and healthy volunteers undergoing routine procedures.

Why it matters

Who can join: the full rules

* SUBJECT INCLUSION CRITERIA:

Pediatric or adult subjects with one of the following:

* Diagnosis of any tumor, malignancy, pre-malignant disorder, or suspected premalignant familial syndromes, regardless, of patient age;
* Biological relatives of any patient with a tumor, malignancy, pre-malignant disorder, or suspected familial pre-malignant syndrome, regardless of patient age or the diagnosis of an adult malignancy or pre-malignant disorder;
* Healthy Volunteer without history of malignancy nor a family member currently being treated for cancer who are undergoing surgery, treatment or during well visits;
* Biospecimens can be collected with minimal additional risk to the subject during sampling or procedures required for routine patient care.
* Human samples, specimens and data collected on IRB approved protocols that are now closed
* Ability of subject, Legally Authorized Representative (LAR), or parent/legal guardian of children \<=18 to understand and be willing to sign an IRB-approved informed consent document that permits the use of the tumor and other samples for genomic-based molecular characterization projects.

Inclusion Criteria for Social and Behavioral Outcome Interviews:

* Parent/caregiver of a participating pediatric or adult patient who is being treated for, or who has previously been treated for any form of pediatric cancer.
* Must be able to give consent and sign the informed consent document.
* Able to understand the English language.

EXCLUSION CRITERIA:

None

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting
• Children's National Medical Center
  Washington D.C., District of Columbia, United States Completed
• Children's Hospital of Orange County (CHOC Children's)
  Orange, Florida, United States Withdrawn
• Tisch Cancer Institute, Mount Sinai Medical Center
  New York, New York, United States Withdrawn
• Carolinas Medical Center/Levine Children's Hospital
  Charlotte, North Carolina, United States Withdrawn

Study contacts

• Principal investigator: Rosandra N Kaplan, M.D. — National Cancer Institute (NCI)
• Study coordinator: Donna B Bernstein, R.N.
• Email: bernsted@mail.nih.gov
• Phone: (240) 760-6189

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.