Collecting specimens and data for early detection and prevention of ovarian cancer
Northwestern Ovarian Cancer Early Detection & Prevention Program: A Specimen and Data Study
This study is trying to find better ways to detect and prevent ovarian cancer early by collecting blood and tissue samples from people at high risk.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 6000 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | Female |
| Sponsor | Northwestern University Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Trial ID | NCT00005095 on ClinicalTrials.gov |
What this trial studies
This observational study aims to improve strategies for the early detection and prevention of ovarian cancer, particularly among high-risk populations. It involves the collection of specimens and data to develop sensitive tumor markers and identify new prevention approaches. Participants will undergo periodic specimen collection, including blood and tissue samples, and may complete questionnaires to assess psychological functioning. The study focuses on understanding and managing ovarian cancer and related gynecological malignancies.
Who should consider this trial
Good fit: Ideal candidates include women at increased risk for ovarian cancer due to family history or genetic predisposition.
Not a fit: Patients without a family history of ovarian cancer or those not deemed at increased risk by a genetic counselor may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection methods and prevention strategies for ovarian cancer, potentially saving lives.
How similar studies have performed: Other studies have shown promise in developing early detection methods for ovarian cancer, making this approach both relevant and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
DISEASE CHARACTERISTICS:
* Meets one of the following criteria:
* Considered to be at increased risk for developing ovarian cancer, as defined by one of the following:
* Has at least one first-degree relative (mother, sister, or daughter) with ovarian, primary peritoneal, or fallopian tube cancer
* Has at least two first or second degree relatives diagnosed before age 50 with either ovarian, primary peritoneal, fallopian tube, and/or pancreatic cancer who have tested positive for hereditary cancer syndrome that includes an increased risk of gynecologic cancer (e.g., BRCA1/2 or Lynch Syndrome)or have increased risk as deemed by a certified genetic counselor
* A personal or family history of a hereditary cancer syndrome that includes an increased risk of gynecologic cancer
* Increased risk as deemed by a certified genetic counselor
* Undergoing surgery for a gynecologic condition, including any of the following:
* Diagnosis of a reproductive cancer
* Benign gynecological condition (e.g., uterine leiomyomata, endometriosis, pelvic inflammatory disease, or follicular or corpus luteum ovarian cysts)
* Highly suspicious adnexal mass
* Risk-reducing prophylactic oophorectomy
PATIENT CHARACTERISTICS:
Age
* Between the ages of 18 and 80
Where this trial is running
Chicago, Illinois
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University — Chicago, Illinois, United States (Recruiting)
Study contacts
- Study coordinator: Takelia Walker
- Email: takelia-watson@northwestern.edu
- Phone: 3125034802
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.