Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Using a nerve block to relieve acute back pain in the emergency department

Official title: Erector Spinae Plane Block for Acute Back Pain in the Emergency Department

Run by Rush University Medical Center · NCT06745453 · Data updated 2026-11-12

This study is testing if a nerve block can help adults with acute low back pain in the emergency department feel better and recover faster compared to a placebo.

More Low Back Pain trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment62 (estimated)
SponsorRush University Medical Center
Academic / other
Locations1 site (Chicago, Illinois)
StatusRecruiting
StartedFebruary 3, 2025
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedMarch 12, 2026
Trial IDNCT06745453 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older presenting with isolated low back pain for less than 6 weeks.

Probably not a fit

Patients who do not speak English or Spanish, are incarcerated, pregnant, allergic to amide-type local anesthetics, or have critical illnesses may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of the erector spinae plane block (ESPB) in reducing pain for adults with low back pain who visit the emergency department. Participants will receive either the ESPB or a placebo injection and will report their pain levels for up to 120 minutes, as well as their pain, disability, and return to work status after 7 days. The study seeks to determine both short-term and longer-term benefits of the ESPB compared to a non-active treatment.

Why it matters

Potential benefit: If successful, this approach could provide significant pain relief and improve recovery outcomes for patients with acute low back pain.

How similar studies have gone: Other studies have shown promising results with similar nerve block techniques, suggesting potential effectiveness for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adults (age ≥18 years) presenting to the emergency department with isolated low back pain present less than 6 total weeks.

Exclusion Criteria:

* Do not speak English or Spanish as a primary language
* Are incarcerated
* Have a known pregnancy
* Are allergic to amide-type local anesthetics
* Are unable to tolerate positioning for the procedure
* Have a critical illness precluding the ability to perform the procedure.

Where it's running

  • Rush University Medical Center
    Chicago, Illinois, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.