Condition

Chronic Low-back Pain clinical trials and research

• 71Clinical trials
• 60NIH research projects
• 1New in 30 days
• 27Countries

Newest Chronic Low-back Pain clinical trials

All recruiting trials (71)

• Ultrasound-Guided Thoracolumbar Fascia Injection for Chronic Low Back Pain in Type 2 Diabetes

  This trial tests whether an ultrasound-guided injection into the thoracolumbar fascia, added to standard care, helps reduce chronic low back pain in adults with type 2 diabetes.

  Recruiting Kanuni Sultan Suleyman Training and Research Hospital · Küçükçekmece, Istanbul · NCT07927530

• Subcutaneous Fat, Back Muscles, and Spine Shape in Back Pain Patients

  This study tests whether body fat under the skin and features of back muscles and spine joints are linked to lumbar facet joint degeneration in adults with chronic low back pain.

  Recruiting Marmara University · Istanbul, Istanbul · NCT07860697

• See if serum BDNF levels relate to outcomes in chronic low back pain

  This study tests whether blood BDNF levels can help predict how patients with chronic low back pain will do over time.

  Recruiting Keimyung University Dongsan Medical Center · Daegu, Daegu · NCT07776379

• Correlating periostin levels with spinal degeneration in back pain

  This study tests whether periostin levels in the intervertebral disc relate to the severity of disc degeneration in people with chronic low back pain and spinal stenosis.

  Recruiting Keimyung University Dongsan Medical Center · Daegu, Daegu · NCT07776366

• Palmitoylethanolamide for Central Sensitisation and Neuroinflammation in Chronic Low Back Pain

  A treatment with palmitoylethanolamide is being tried to see if it helps people with chronic low back pain who have nerve-related pain and disc problems.

  Recruiting Beni-Suef University · Banī Suwayf · NCT07772141

• Multichannel neuromuscular stimulation plus core exercise for chronic low back pain

  This study tests two multichannel neuromuscular electrical stimulation programs added to a core exercise plan to see if they help adults with chronic non-specific low back pain.

  Recruiting Uskudar University · Şırnak · NCT07760142

• Algorithm-informed care to find the best pain treatment for chronic low back pain

  This study tests whether an algorithm that uses a patient’s symptoms, history, and lifestyle can help pick the best treatment from physical therapy, duloxetine, acupressure, or PRISM-CBT for people with chronic low back pain.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07731750

• Ultrasound-Guided Proximal Superior Cluneal Nerve Block for SCNE

  This study tests how well an ultrasound-guided nerve block works for people with superior cluneal nerve entrapment and chronic low back pain.

  Recruiting Gaziosmanpasa Research and Education Hospital · Gaziosmanpaşa, Istanbul · NCT07712406

• High-Intensity Laser Therapy vs Epidural Injection for Chronic Lumbar Disc Herniation Pain

  This trial tests whether high-intensity laser therapy can relieve chronic low back and leg pain as well as a transforaminal epidural steroid injection in adults with lumbar disc herniation.

  Recruiting Ankara City Hospital Bilkent · Ankara · NCT07688915

• Auricular vagus nerve stimulation added to care for high-impact chronic low back pain

  This trial tests whether adding the VIVO device to standard care helps adults with high-impact chronic low back pain function better and have less pain compared to standard care alone.

  Recruiting Algemeen Ziekenhuis Maria Middelares · Ghent, Oost-Vlaanderen · NCT07681336

• Cryoneurolysis for Chronic Pain: 6- and 12-Month Outcomes in Routine Care

  This study tests whether cryoneurolysis, done as part of standard care for people with chronic pain, leads to meaningful improvements over 6 to 12 months.

  Recruiting Yale University · Old Saybrook, Connecticut · NCT07639060

• Leisure activities and quality of life in chronic low back pain

  This study tests whether engaging in leisure activities is linked to better quality of life for adults with chronic low back pain.

  Recruiting Centre Hospitalier Valida · Brussels and 1 other locations · NCT07467499

• Ultrasound-guided stabilization exercises for lumbosacral (low back) pain

  This trial will try using ultrasound biofeedback during stabilization exercises to see if it reduces pain and improves balance, mobility, and quality of life in adults aged 30–65 with chronic lumbosacral (low back) pain.

  Recruiting University of Rzeszow · Tarnów, Małopolska · NCT07463729

• Virtual reality rehabilitation compared with conventional therapy for chronic low back pain

  This study will test whether adding non-immersive virtual reality training to standard physiotherapy helps adults 40–65 with chronic low back pain reduce pain and improve movement and balance.

  Recruiting University of Rzeszow · Sanok, Podkarpackie Voivodeship · NCT07463105

• Mindfulness meditation plus ear vagus nerve stimulation for chronic low back pain and depressive symptoms

  This study will test whether a home-based mindfulness meditation program combined with gentle ear vagus nerve stimulation can reduce pain and depressive symptoms in community-dwelling older adults with chronic low back pain.

  Recruiting Florida State University · Tallahassee, Florida · NCT07415941

• Thoracolumbar fascia mobilization versus ultrasound-guided 5% dextrose injection for chronic low back pain

  This study will try two treatments—hands-on thoracolumbar fascia mobilization and ultrasound-guided 5% dextrose injections—to see if they reduce pain and improve movement and function in adults with chronic low back pain who have not adequately improved with medical treatment.

  Recruiting Ankara City Hospital Bilkent · Ankara, Altındağ · NCT07241559

• Time‑variant pulse spinal cord stimulation for chronic low back and leg pain

  This trial will test whether time‑variant pulse spinal cord stimulation using the Boston Scientific WaveWriter Alpha system can reduce chronic low back or leg pain in adults who have not found relief from other treatments.

  Recruiting at 7 sites Boston Scientific Corporation · Greenwood, Colorado and 6 other locations · NCT07190807

• Physical activity and exercise to help disability and mental health in older adults with chronic low back pain

  This study tests whether a combined exercise program plus a tailored daily activity plan can help reduce disability and improve sleep and mood in people aged 60 and older with chronic low back pain.

  Recruiting Al-Azhar University · Gaza, Gaza Strip · NCT07178561

• Expressive art therapy plus exercise for older adults with chronic low back pain

  This project will try combining group expressive art activities with supervised exercise to see if it reduces pain and improves function in adults aged 60 and over with chronic low back pain.

  Recruiting The Hong Kong Polytechnic University · Hong Kong · NCT07141082

• Adding radial shock wave therapy to physical therapy for chronic low back pain

  This study tests whether adding radial extracorporeal shock wave therapy (ESWT) to standard physical therapy helps adults with chronic low back pain reduce pain, disability, and change ultrasound measures of back muscles.

  Recruiting Pamukkale University · Denizli · NCT07132762

• 6-minute Step Test for Adults with Chronic Low Back Pain

  This project will test whether the 6-minute step test can replace the 6-minute walk test to measure functional capacity in adults aged 18–65 with chronic low back pain.

  Recruiting Kirsehir Ahi Evran Universitesi · Kırşehir · NCT07028034

• Active music sessions to help people with chronic low back pain

  This program will try active music-based sessions to see if they help adults with chronic low back pain improve thinking, sensitivity to stimuli, pain-related worry, and overall quality of life.

  Recruiting Texas Woman's University · Denton, Texas · NCT06940063

• Immediate effects of spinal manipulation, exercise, and placebo on movement in chronic low back pain

  This project will try a single session of spinal manipulation, targeted trunk exercises, and an open-label placebo to see which produces immediate improvements in movement and pain for adults with chronic non-specific low back pain.

  Recruiting Karolinska Institutet · Huddinge · NCT06891625

• Foot reflexology treatment for chronic low back pain

  This study is testing whether foot reflexology can help people with chronic low back pain feel better and improve their quality of life.

  Recruiting Fu Jen Catholic University Hospital · New Taipei City · NCT06828016

• Minimally-invasive procedure for vertebrogenic back pain

  This study looks at how well the Intracept™ procedure works for people with chronic low-back pain caused by vertebrogenic issues.

  Recruiting at 19 sites Boston Scientific Corporation · Flagstaff, Arizona and 21 other locations · NCT06827262

• Needle-free ear cryo-stimulation and brain imaging for chronic low back pain

  This trial will test whether needle-free ear cryo-stimulation can change brain activity and reduce pain in adults who have had daily low back pain for at least six months.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06825390

• Telerehabilitation for chronic low back pain

  This study tests whether video-based physical therapy can help people with chronic low back pain just as well as traditional in-person therapy.

  Recruiting at 3 sites Johns Hopkins University · Baltimore, Maryland and 2 other locations · NCT06821607

• Assessment and treatment of low back pain using ultrasound and osteopathic techniques

  This study is trying to see if using ultrasound and hands-on techniques can help people with low back pain by looking closely at a specific part of the back called the thoracolumbar fascia.

  Recruiting Edward Via Virginia College of Osteopathic Medicine · Blacksburg, Virginia · NCT06818175

• Evaluating exercise capacity and muscle strength in people with chronic low back pain

  This study is testing how well people with chronic low back pain can exercise their upper body and whether that relates to their muscle strength and overall quality of life.

  Recruiting Kirsehir Ahi Evran Universitesi · Kırşehir · NCT06806514

• Comparing two treatments for chronic low back pain

  This study is testing whether two different treatments for chronic low back pain can help reduce pain and improve movement for people suffering from this condition.

  Recruiting Cairo University · Cairo · NCT06796881

• Comparing dry needling and soft tissue mobilization for hamstring tightness

  This study is testing whether dry needling or soft tissue mobilization helps people with hamstring tightness and chronic low back pain feel better and move more easily.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT06751160

• Using virtual reality in a program to help restore function for chronic low back pain

  This study is testing whether using virtual reality in a rehabilitation program can help people with chronic low back pain feel less afraid of moving, improve their motor skills, reduce pain, and boost their overall function.

  Recruiting at 5 sites University Hospital, Angers · Angers and 4 other locations · NCT06724679

• Multidisciplinary treatment for chronic low back pain

  This study is testing a new program that combines education, therapy, and exercise to see if it can help people with chronic low back pain feel better and improve their quality of life compared to regular treatment.

  Recruiting University of Barcelona · Barcelona, Barcelona and 1 other locations · NCT06679205

• tACS to reduce chronic low back pain

  The team will try one month of transcranial alternating current stimulation (tACS) to see if it reduces pain in adults with chronic low back pain.

  Recruiting Phase 2 Massachusetts General Hospital · Charlestown, Massachusetts · NCT06568198

• Using a health app to promote physical activity in people with chronic low back pain

  This study is testing how a health app can help people with chronic low back pain stay active by understanding what motivates them and what challenges they face.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT06517342

• High intensity training supported by technology for chronic low back pain

  This study is testing whether a technology-supported high intensity exercise program can help people with chronic low back pain feel better compared to a moderate intensity program.

  Recruiting at 2 sites Hasselt University · Wilrijk, Antwerpen and 3 other locations · NCT06491121

• Improving health for patients with chronic low back pain in rural areas using telerehabilitation

  This study is testing if telerehabilitation can help people with chronic low back pain in rural areas get better access to physical therapy and improve their pain and disability.

  Recruiting at 2 sites Johns Hopkins University · Baltimore, Maryland and 1 other locations · NCT06471920

• Ketamine-assisted integrative treatment for Veterans with chronic low back pain and depression

  This pilot tests whether ketamine infusions followed by a brief behavioral program can reduce pain interference and improve mood in Veterans with chronic low back pain and depression.

  Recruiting Phase 2 VA Office of Research and Development · Ann Arbor, Michigan · NCT06419439

• Mindfulness meditation for older adults with chronic low back pain

  This study is testing whether mindfulness meditation can help older adults with chronic low back pain feel better and improve their gut health.

  Recruiting Florida State University · Tallahassee, Florida · NCT06384001

• Effects of psilocybin on chronic low back pain and depression

  This study is testing if a single high dose of psilocybin can help people with chronic low back pain and depression feel better.

  Recruiting Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT06355414

• Using an app to help manage chronic low-back pain

  This study is testing whether the SelfBack app can help people with chronic low-back pain manage their symptoms better when it's provided through chiropractors in Alberta.

  Recruiting University of Alberta · Edmonton, Alberta · NCT06347991

• Understanding how spinal cord stimulation affects chronic low back pain

  This study is testing how spinal cord stimulation can help people with chronic low back pain feel better and improve their daily activities.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT06310226

• Comparing lumbar fusion surgery to rehabilitation for chronic low back pain

  This study is testing whether lumbar fusion surgery or a rehabilitation program works better for people aged 20-65 with chronic low back pain lasting more than a year.

  Recruiting at 4 sites Oslo University Hospital · Drammen and 4 other locations · NCT06169488

• Mindfulness-based treatment for chronic low back pain

  This study is testing how well an 8-week mindfulness program helps people with chronic low back pain and what factors might affect their results.

  Recruiting Boston Medical Center · Boston, Massachusetts · NCT06106191

• Clinician satisfaction with the VERABAND wearable activity monitor

  This study will test whether giving wearable VERABAND activity monitors to people with chronic low back pain helps clinicians find the device usable and likely to use in patient care.

  Recruiting at 2 sites University of Michigan · La Jolla, California and 2 other locations · NCT06080464

• Identifying brain markers for chronic low back pain

  This study is testing if brain activity patterns can help predict how chronic low back pain will progress in people who suffer from it.

  Recruiting Stanford University · Palo Alto, California · NCT06025201

• Testing spinal manipulative therapy for chronic low-back pain

  This study tests if spinal manipulative therapy can help people with chronic low back pain feel better and if different types of treatment make a difference.

  Recruiting Université du Québec à Trois-Rivières · Trois-Rivières, Quebec · NCT05986370

• Comparing different treatments for chronic pain conditions

  This study is testing different treatments for chronic pain conditions like osteoarthritis and diabetic neuropathy to see which ones work better than a placebo.

  Recruiting at 36 sites Phase 2 Eli Lilly and Company · Birmingham, Alabama and 63 other locations · NCT05986292

• Understanding brain factors in chronic low back pain

  This study looks at how the brain might be involved in chronic low back pain to help improve diagnosis and treatment for people who have been dealing with this pain for six months or longer.

  Recruiting Université de Sherbrooke · Sherbrooke, Quebec · NCT05963451

• Chromatic Retinal Stimulation to Help With Chronic Pain

  This study tests whether different color light delivered to the retina can reduce pain and pain sensitivity in adults with fibromyalgia or chronic low back pain.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT05956067

• Evaluating a new physiotherapy approach for chronic low back pain in Bangladesh

  This study is testing a new physiotherapy method called STOPS to see if it helps people in Bangladesh with chronic low back pain feel better compared to regular physiotherapy.

  Recruiting Uttara Adhunik Medical College · Dhaka, Uttara · NCT05880212

• Using TENS to treat chronic low back pain

  This study is testing if a device that uses electrical signals can help people with chronic low back pain feel less pain and improve their daily activities.

  Recruiting University of Hartford · West Hartford, Connecticut · NCT05812885

• Behavioral weight reduction program for overweight or obese patients with chronic low back pain

  This study tests if a weight loss program that includes education about pain and special exercises can help overweight or obese people with chronic low back pain feel better compared to just the education and exercises alone.

  Recruiting at 2 sites Vrije Universiteit Brussel · Brussels and 1 other locations · NCT05811624

• Motivational support for chronic low back pain after rehabilitation

  This study is testing a new app that provides motivational support to help people with chronic low back pain stay active and feel better after finishing a rehabilitation program.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT05780021

• Transcranial stimulation combined with physiotherapy for chronic low back pain

  This study is testing if combining a brain stimulation technique with physical therapy can help people with chronic low back pain feel better and move more freely.

  Recruiting University Hospital, Geneva · Geneva · NCT05757609

• Using a smartphone app to track pain and mood changes

  This study is testing a smartphone app to track pain and mood changes in people with chronic pain and healthy individuals to see how these factors affect pain over time.

  Recruiting Brown University · Providence, Rhode Island · NCT05754190

• Mobile neurofeedback treatment for chronic low back pain

  This study is testing whether a mobile app that helps train the brain to relax can reduce chronic low back pain for people who suffer from it.

  Recruiting Duke University · Durham, North Carolina · NCT05669027

• Linking podiatry/posturology balance measurements to pain in chronic low back pain

  We will test whether balance measurements taken by a podiatrist-posturologist are related to pain, movement problems, and fear of movement in people with chronic low back pain.

  Recruiting University Hospital, Lille · Valenciennes · NCT05540548

• Assessing movement control in patients with chronic low back pain

  This study is trying to see if measuring how people with chronic low back pain move can help therapists better understand their movement problems and improve their treatment.

  Recruiting University Hospital, Brest · Brest, Finistère · NCT05511012

• Minimally invasive artificial disc replacement for chronic low back pain

  This study is testing a new device for replacing damaged discs in the lower back to see if it can help people with chronic back pain feel better without the downsides of traditional surgery.

  Recruiting at 4 sites Spinal Stabilization Technologies · Medellín, Antioquia and 10 other locations · NCT05508360

• Effects of high frequency electrical current on muscle pain and function

  This study is testing if a new type of electrical therapy called TECAR can help people with muscle pain and movement problems feel better compared to a standard treatment.

  Recruiting at 2 sites Aristotle University Of Thessaloniki · Kavala and 1 other locations · NCT05345015

• Non-invasive spinal cord stimulation for chronic low back pain relief

  This study is testing a new way to relieve chronic low back pain using a non-invasive method that sends electrical signals to the spinal cord, helping people feel better without surgery.

  Recruiting University of California, San Francisco · San Francisco, California · NCT05265000

• Registry for chronic low back pain and healthy controls

  This study is trying to learn more about chronic low back pain by comparing people who have it with those who don’t, to see how pain affects their lives and what treatments work best.

  Recruiting University of North Texas Health Science Center · Fort Worth, Texas · NCT04853732

• Weight reduction program for chronic low-back pain

  This study is testing if a weight loss program combined with pain education and exercise can help overweight people with chronic low back pain feel better.

  Recruiting at 2 sites Vrije Universiteit Brussel · Brussels and 1 other locations · NCT04824248

• Evaluating a new needle technique for treating chronic low-back pain

  This study is testing a new needle technique for treating chronic low-back pain to see if it works better than regular medical care for adults who have been in pain for at least six months.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT04730700

• Brain imaging to predict response to spinal cord stimulation for chronic low back pain

  This study is testing if brain scans can help predict how well spinal cord stimulation will work for people with chronic low back pain.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT04658628

• Follow-up on outcomes after surgery with the LISA implant for back pain

  This study looks at how well the LISA implant works and its safety for people who have had surgery for chronic low-back pain.

  Recruiting at 5 sites Backbone · Silkeborg and 4 other locations · NCT04631133

• Evaluating pain treatment effectiveness for veterans with chronic low back pain

  This study is testing different non-surgical treatments for chronic low back pain in veterans to see which ones help them feel better.

  Recruiting at 13 sites VA Office of Research and Development · Phoenix, Arizona and 18 other locations · NCT04142177

• Deep brain stimulation for chronic low back pain

  This study is testing if deep brain stimulation can help people with chronic low back pain who haven't found relief from regular treatments.

  Recruiting University of California, Los Angeles · Los Angeles, California and 1 other locations · NCT04085406

• Evaluating osteopathic treatment for chronic low back pain management

  This study tests if adding real osteopathic treatment to regular care can help people with chronic low back pain feel less pain compared to those who only get standard treatment or a fake treatment.

  Recruiting Clinique Pasteur · Toulouse · NCT03836248

• Using focused ultrasound and radiofrequency to treat low back pain from facet joint issues

  This study is testing whether focused ultrasound or radiofrequency treatment can help people with low back pain from facet joint issues feel better and improve their daily life.

  Recruiting Taipei Medical University Hospital · Taipei, Please Select · NCT03168802

NIH-funded research (newest 40 of 60)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Ketamine-assisted care plan to help Veterans with chronic back pain and depression

  A program for Veterans with chronic low back pain and depression that uses ketamine infusions followed by a brief narrative therapy to sustain relief from pain and mood improvement.

  NIH research Veterans Health Administration · Ann Arbor, United States · NIH-11533116

• Savoring Meditation for Chronic Low Back Pain patients

  A study tests a brief mindfulness-based practice called Savoring Meditation to help people with chronic low back pain feel better emotionally and manage pain in daily life.

  NIH research University of Virginia · Charlottesville, United States · NIH-11465428

• Chronic Low Back Pain in Older Adults and Hip Impairments

  A study to help older adults with chronic low back pain, by looking at how hip problems affect their pain and function and testing tailored non-drug treatments.

  NIH research University of Delaware · Newark, UNITED STATES · NIH-11447991

• Mechanical signs from the spine’s discs that predict when back pain becomes long-lasting

  A Duke study aims to use new imaging and personal factors to see if the mechanical health of spinal discs can predict when acute low back pain becomes chronic.

  NIH research Duke University · Durham, United States · NIH-11446556

• Genetic predictors of recovery and surgical outcomes for Veterans with chronic low back pain and lumbosacral spine disorders

  This project uses VA health records and genetic information to find DNA markers linked to how Veterans fare with chronic low back pain and related spine conditions.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11446450

• Personalized multicomponent therapy for chronic low back pain using smart patient-based algorithms

  A U-Michigan-led effort tests a personalized approach to chronic low back pain by tailoring several treatments to individual patients using smart, data-driven decision rules.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11418354

• Epigenetic drivers of chronic low back pain

  A patient-friendly look at how DNA methylation might influence disc-related back pain and potential new ways to treat it beyond opioids.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11418084

• Deep Brain Stimulation for Chronic Low Back Pain

  A new brain-targeted therapy is tested to help people with long-standing, hard-to-treat low back pain that hasn’t improved with other treatments.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11417113

• Improving back-pain care in rural areas with tele-physical therapy

  This project tests a tele-rehabilitation program to help adults with chronic low back pain in rural communities access physical therapy and reduce opioid use.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11412950

• Mechanistic insights into chronic low back pain using patient tissues

  Researchers are studying nerve and tissue changes in people with chronic low back pain who are having spine surgery to find new clues that could lead to better treatments.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11399406

• Psilocybin for Chronic Back Pain: Brain Signals and Real-World Therapy Outcomes

  A patient-facing study will test whether a carefully controlled psilocybin treatment can improve body awareness and enhance physical therapy outcomes for people with chronic low back pain.

  NIH research Yale University · New Haven, United States · NIH-11359203

• Increase use of non-drug therapies for chronic low back pain

  A study to help people with chronic low back pain use proven non-pharmacological therapies more often, by empowering patients to advocate for these treatments in their networks.

  NIH research Rand Corporation · Santa Monica, United States · NIH-11358692

• Cannabis Coaching for Chronic Low Back Pain: A Multi-Site Feasibility Study

  A multi-site study tests a cannabis-coaching program designed to help people with chronic low back pain use legal cannabis products safely and effectively.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11358127

• Mindfulness-based brain science to reduce pain and opioid use in chronic back pain

  A study at UC San Diego tests how Mindfulness-Oriented Recovery Enhancement may help people with chronic low back pain use fewer opioids by changing brain activity.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11348866

• An adaptive plan to help pain after CBT for insomnia in people with chronic back pain

  A patient-facing program will test a supplemental, hopeful approach added to standard CBT for insomnia to see if it can reduce pain for people who have chronic low back pain and insomnia.

  NIH research University of Virginia · Charlottesville, United States · NIH-11332862

• Auricular stimulation for chronic low back pain: brain changes measured with noninvasive imaging

  A noninvasive study tests whether ear-based stimulation changes brain activity and connectivity in healthy volunteers and people with chronic low back pain.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11325702

• Virtual reality program to reduce chronic low back pain

  This project will see if a virtual-reality, brain-targeting treatment can reduce long-term low back pain in adults.

  NIH research Cognifisense, INC. · Sunnyvale, United States · NIH-11322088

• Acupuncture for Medicare Beneficiaries with Chronic Low Back Pain

  This project looks at how coverage of acupuncture for chronic low back pain in Medicare beneficiaries affects outcomes, access, and costs.

  NIH research Southern California Univ of Health Scis · Whittier, United States · NIH-11311347

• How fat builds up in back muscles with chronic low back pain

  Researchers will use advanced MRI plus movement and muscle tests to link patterns of fat in back muscles to symptoms in people with chronic low back pain.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11306684

• Brain changes in chronic low back pain across ages and sexes

  This project looks for brain-based markers of long-term low back pain and how aging and biological sex change those brain patterns for people with chronic low back pain.

  NIH research University of Rochester · Rochester, United States · NIH-11295443

• How race and income affect long‑term low back pain

  This project looks at why adults of different races and socioeconomic backgrounds, especially Black and White adults, experience different levels of long‑lasting low back pain.

  NIH research Washington University · Saint Louis, United States · NIH-11251322

• UCSF REACH: smarter understanding of chronic low back pain using big data and models

  A big NIH grant will help UCSF build and test a data-driven model to understand chronic low back pain and guide better care.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11211838

• Remote physical therapy to ease chronic low back pain and cut opioid use in rural communities

  This project offers remote physical therapy to people with long-term low back pain in rural areas to help them move better and depend less on opioid pain medicines.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11194520

• DNA methylation and chronic low back pain

  This project looks at how DNA on/off switches (DNA methylation) change in people with long-term low back pain to find new ways to treat disc-related pain.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11181647

• Understanding causes of chronic low back pain

  We are using advanced cell-level RNA sequencing on nerves and spine tissues from people having surgery for chronic low back pain to look for biological changes that may cause ongoing pain.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11171505

• Improving access to physical therapy for chronic low back pain in rural areas using telehealth.

  This study is looking to make physical therapy easier for people with chronic low back pain living in rural areas by using online sessions, so you can get the help you need without worrying about travel or finding a therapist nearby.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11163083

• Exploring acupuncture's effects on chronic low back pain for Medicare patients

  This study is exploring how acupuncture might help older adults on Medicare who have chronic low back pain, looking at how well it works, how safe it is, and whether it's a good option compared to regular pain medications, while also checking how easy it is for them to get acupuncture and what challenges they might fac

  NIH research Southern California Univ of Health Scis · Whittier, United States · NIH-11144531

• Improving pain outcomes for patients with chronic low back pain and insomnia

  This study is looking for ways to help people with chronic low back pain and trouble sleeping by using a special therapy that combines techniques to improve sleep and boost positive feelings, so if you're struggling with these issues, you might find this research helpful!

  NIH research University of Virginia · Charlottesville, United States · NIH-11122117

• Using virtual reality therapy to reduce chronic low back pain

  This study is testing a new virtual reality therapy that helps people with chronic low back pain by using fun and immersive experiences to change how their brain processes pain, and it's looking for participants to see if this therapy works better than regular treatments.

  NIH research Cognifisense, INC. · Sunnyvale, United States · NIH-11112333

• Exploring how mindfulness can help reduce chronic low back pain and opioid use

  This study is looking at how a mindfulness program can help people with chronic low back pain feel better and use fewer pain medications, while also exploring how these mindfulness practices affect the brain.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11098663

• Understanding how aging and sex affect brain mechanisms in chronic low-back pain

  This study is looking at how chronic low-back pain affects the brain differently in older adults and between men and women, with the hope of finding better ways to measure pain and improve treatment options for everyone dealing with this condition.

  NIH research University of Rochester · Rochester, United States · NIH-11064816

• Understanding how fat infiltration in back muscles affects chronic low back pain

  This study is looking at how fat buildup in the muscles around the spine might be linked to chronic low back pain, and it's for people who experience this kind of pain to help find better treatment options just for them.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11061362

• Finding genetic factors that affect outcomes for Veterans with chronic low back pain

  This study is looking at how your genes might help doctors choose the best treatment for Veterans with ongoing low back pain or those needing surgery, so they can get better care and feel better faster.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11055348

• Investigating brain changes from ear stimulation in chronic low back pain patients

  This study is looking at how a gentle ear treatment called auriculotherapy can help ease chronic low back pain by checking how it affects brain activity, and it's open to both healthy people and those dealing with back pain.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11020630

• Understanding how social factors affect the transition from acute to chronic low back pain

  This study is looking at how things like feeling lonely or being socially active can affect whether people with short-term low back pain end up with long-term pain, and it's for anyone who's dealing with acute low back pain and wants to understand how their social life might play a role in their recovery.

  NIH research Duke University · Durham, United States · NIH-10998092

• Exploring how race and socioeconomic factors affect chronic low back pain

  This study is looking at how things like race and income affect chronic low back pain, hoping to find out why some people experience more pain and disability than others, so we can create better treatments for everyone.

  NIH research Washington University · Saint Louis, United States · NIH-10994111

• Mindfulness plus AI to personalize care for chronic low back pain

  Using AI and wearable and survey data to find which adults with chronic low back pain are likely to benefit from a mindfulness-based program.

  NIH research Worcester Polytechnic Institute · Worcester, United States · NIH-10992095

• Understanding the genetic factors behind chronic low back pain

  This study is looking at how changes in your genes might be linked to chronic low back pain from disc problems, and it’s for people who experience this kind of pain; by sharing some samples and information, you can help researchers find new ways to ease your pain and improve your life.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10978456

• Using virtual reality to enhance acupuncture treatment for chronic low back pain

  This study is exploring a new way to help people with chronic low back pain by using virtual reality to create an acupuncture experience in their minds, which might help those who haven't found relief with regular treatments.

  NIH research Massachusetts Neuro Technology, INC. · Weston, United States · NIH-10976167

• Investigating how genetic factors influence chronic low back pain differences among racial groups

  This study is looking at how genetic changes and stress hormones might affect chronic low back pain differently in Black and white people, and it aims to help us understand how resilience can influence pain experiences.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-10974708

Related topics

Quick answers

How many Chronic Low-back Pain clinical trials are recruiting right now?

71, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 27 countries. The most sites are in United States (29 trials), Turkey (Türkiye) (9 trials), France (7 trials), Belgium (5 trials), Canada (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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