Condition

Chronic Low Back Pain (CLBP) clinical trials and research

• 31Clinical trials
• 1New in 30 days
• 15Countries

Newest Chronic Low Back Pain (CLBP) clinical trials

All recruiting trials (31)

• A novel multi angular isometric lumbar exercise for chronic low back pain

  This trial tests MAILE, a new lumbar exercise method, to see if it helps adults with nonspecific chronic low back pain more than standard lumbar stabilization and core exercises.

  Recruiting Hamad Medical Corporation · Doha · NCT07908693

• Understanding brain activity in chronic low back pain with movement and biometric profiling

  This observational study tests brain activity patterns in adults with chronic non-specific low back pain who have neural mechanosensitivity, using wearable OPM-MEG during rest and movement, and compares them to healthy controls.

  Recruiting Aristotle University Of Thessaloniki · Thessaloniki, Central Macedonia · NCT07846163

• BDNF Levels in Spine Pain Patients and Disc Degeneration

  This observational study tests whether blood levels of BDNF relate to disc degeneration and inflammation in people with chronic low back pain.

  Recruiting Keimyung University Dongsan Medical Center · Daegu, Daegu · NCT07807839

• Pain phenotypes in people with chronic low back pain

  This study tests whether people with chronic low back pain can be grouped into pain types (nociceptive, neuropathic, nociplastic, or mixed) based on a clinical algorithm.

  Recruiting Kutahya Health Sciences University · Kütahya, Türkiye · NCT07766200

• Pain Reprocessing Therapy for Chronic Low Back Pain

  This study tests whether Pain Reprocessing Therapy can help adults with chronic low back pain by comparing it to a monitoring and education program over eight weeks.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07696741

• VIVO 2nd GEN add-on for chronic low back pain with multimodal therapy

  This pilot trial tests whether adding VIVO 2nd GEN auricular vagus nerve stimulation to standard multimodal pain therapy helps adults with chronic low back pain.

  Recruiting Aurimod GmbH · Klagenfurt, Carinthia · NCT07628179

• How exercise affects the immune system and brain in chronic low back pain

  This trial will test whether a 12-week online exercise program changes immune activity, brain function, and pain for adults with chronic low back pain compared with a waitlist group.

  Recruiting McGill University · Montreal, Quebec · NCT07497425

• Acupuncture for myofascial back pain: imaging and pain outcomes

  This study tests whether true acupuncture helps people with chronic low back pain due to myofascial pain syndrome more than sham acupuncture, and whether total-body PET imaging picks up tissue changes related to pain.

  Recruiting University of California, Davis · Sacramento, California · NCT07494162

• Bone marrow concentrate injection added to lumbar microdiscectomy

  This trial tests whether adding a bone marrow aspirate concentrate injection during lumbar microdiscectomy helps adults recover better than surgery alone.

  Recruiting Weill Medical College of Cornell University · Manhattan, New York · NCT07386548

• PEMM for women with chronic low back pain and urinary leakage

  This study will try pelvic external myofascial mobilization (PEMM) with core exercises to see if it lowers pain, reduces disability, and improves urinary leakage and mental health in women with chronic low back pain and urinary incontinence.

  Recruiting Hamad Medical Corporation · Doha, Baladiyat ad Dawhah · NCT07351851

• JHG002 pharmacopuncture versus TENS for chronic low back pain

  This trial will test whether JHG002 pharmacopuncture reduces pain more than standard physical therapy with TENS in adults with chronic low back pain lasting at least six months.

  Recruiting at 4 sites Jaseng Medical Foundation · Seoul, Gangdong-gu and 3 other locations · NCT07304076

• Boosting resilience and reducing chronic low back pain by treating sleep and adding meditation or pain education

  This program tests whether adding savoring meditation or extra pain education to a cognitive behavioral sleep program helps adults with chronic low back pain and insomnia have less pain.

  Recruiting Phase 2 University of Virginia · Charlottesville, Virginia · NCT07298941

• Comparing two lumbar radiofrequency ablation approaches for chronic low back pain

  This trial will test whether two types of lumbar radiofrequency ablation help adults with chronic low back pain feel and move better than a simulated procedure.

  Recruiting at 2 sites University of Washington · Atlanta, Georgia and 2 other locations · NCT07222462

• Spinal cord–induced muscle stimulation for chronic low back pain

  This study will test a spinal cord-induced muscle stimulation device (MuscleSCS) to see if it reduces chronic low back pain in adults who have predominant back pain and meet specific SCS response criteria.

  Recruiting WVU Medicine Thomas Hospitals · Charleston, West Virginia · NCT07215104

• Acceptance and Commitment Therapy plus exercise for older adults with chronic low-back pain

  This trial will test whether combining Acceptance and Commitment Therapy (ACT) with exercise and back-care education helps people aged 60 and over manage chronic low-back pain.

  Recruiting The Hong Kong Polytechnic University · Hong Kong · NCT07211464

• How Osteopathic Treatment Might Help the Leg and Foot in Chronic Low Back Pain

  This pilot test will see if osteopathic manipulative treatment (OMT) can improve pain, function, and well‑being in adults with chronic low back pain.

  Recruiting Edward Via Virginia College of Osteopathic Medicine · Auburn, Alabama · NCT07193212

• Exploring how people with back pain move over time

  This study tests how people with acute or chronic low back pain move and adapt in daily life using smartphone sensors to track motion.

  Recruiting Bern University of Applied Sciences · Bern · NCT07176845

• Lumbar stabilization versus back extension/endurance exercises for female university students with chronic low back pain

  This will test whether lumbar stabilization exercises or back extension/endurance exercises better reduce chronic low back pain and improve function in female university students.

  Recruiting Cairo University · Cairo · NCT07163117

• Adding osteopathic manipulation to VA care for chronic low back pain

  This trial will test whether adding osteopathic manipulative therapy—hands-on techniques that move muscles and joints—to usual VA care helps veterans with chronic low back pain.

  Recruiting Edward Hines Jr. VA Hospital · Hines, Illinois · NCT07161661

• Group art therapy combined with exercise for adults with chronic low back pain

  This project will try supervised group art therapy together with exercise to see if it reduces pain and improves function and quality of life for adults aged 18–59 with chronic low back pain.

  Recruiting The Hong Kong Polytechnic University · Hong Kong, Hong Kong and 1 other locations · NCT07141069

• Testing the NUN biomarker to guide dry needling for myofascial low back pain.

  This study will try to see if the NUN biomarker changes after dry needling and can predict who with chronic myofascial low back pain will feel better.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07133139

• Brain stimulation plus psychologically informed physiotherapy for chronic low back pain in Veterans

  This study will test whether adding non-invasive brain stimulation to psychologically informed physiotherapy helps Veterans with chronic low back pain and high psychological risk factors reduce pain and improve physical function.

  Recruiting Laval University · Québec, Quebec and 1 other locations · NCT06999772

• Examining the links between chronic low back pain and insomnia

  This study is trying to see how chronic low back pain and insomnia are connected by looking at brain changes and how they affect each other in different groups of people.

  Recruiting Vrije Universiteit Brussel · Leuven · NCT06973837

• Isometric exercises and immediate pain sensitivity in chronic low back pain

  This trial will try short isometric exercises to see if they quickly reduce pain sensitivity and current pain in adults with chronic low back pain.

  Recruiting Taif University · Bisha, 'Asir Region · NCT06963658

• Improving movement quality and balance in people with chronic low back pain through trunk muscle training

  This study is testing whether trunk muscle training can help people with chronic low back pain improve their movement and balance compared to a group that only receives education about back care.

  Recruiting The Hong Kong Polytechnic University · Hong Kong · NCT06944730

• Brain network stimulation to reduce chronic low back pain

  This trial will try a non‑invasive brain stimulation technique called transcranial infraslow grey noise stimulation to reduce pain in adults with chronic low back pain.

  Recruiting University of Otago · Dunedin, Otago · NCT06902233

• Passive versus passive-plus-active hamstring stretching for flexibility in chronic low back pain

  This study will see if adding active hamstring stretches to passive stretches improves flexibility for adults with chronic low back pain.

  Recruiting at 2 sites University Hospital, Clermont-Ferrand · Cébazat, France and 1 other locations · NCT06888895

• Understanding the impact of disability and fear on quality of life in chronic low back pain

  This study looks at how disability and fear affect the quality of life for people aged 18-50 with chronic low back pain to see how these factors are connected.

  Recruiting Istanbul Arel University · Istanbul, Buyukcekmece · NCT06869668

• Multidisciplinary treatment for chronic low back pain

  This study is testing a new program that combines education, therapy, and exercise to see if it can help people with chronic low back pain feel better and improve their quality of life compared to regular treatment.

  Recruiting University of Barcelona · Barcelona, Barcelona and 1 other locations · NCT06679205

• Online therapy for managing pain in fibromyalgia and lupus patients

  This study is testing an online therapy called Brief Pain Exposure Therapy to see if it can help adults with fibromyalgia and lupus manage their pain and improve their overall well-being.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT06208514

• Investigating how cannabis helps relieve pain

  This study is testing how vaporized cannabis helps relieve pain by looking at how it affects the brain while participants feel controlled heat.

  Recruiting Early Phase 1 University of California, San Diego · La Jolla, California · NCT04982965

Related topics

Quick answers

How many Chronic Low Back Pain (CLBP) clinical trials are recruiting right now?

31, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in United States (10 trials), Hong Kong (3 trials), Canada (3 trials), Qatar (2 trials), South Korea (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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