Investigating factors affecting pregnancy-related lumbopelvic pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study explores the multifactorial causes of pregnancy-related lumbopelvic pain (PLPP) by examining proprioceptive, fear-related, and inflammatory factors in women during their third trimester and postpartum. It aims to identify differences in sensory input, psychological factors, and inflammatory markers between women with and without PLPP. The study will assess these factors over time to understand their correlation and impact on pain persistence. By focusing on both physical and psychological aspects, the research seeks to provide a comprehensive understanding of PLPP.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Informed consent to participate
* 18-40 years old
* Pregnant
* Singleton pregnancy (confirmed through ultrasound)
* No current PLPP
* Dutch- or English-speaking

Exclusion Criteria:

* Pregnant for more than 16 weeks
* Currently experiencing PLPP, or having had PLPP during the index pregnancy
* History of surgery or major trauma to the spine or pelvis, major trauma or surgery to the lower limbs more than 2 years ago with current residual symptoms (e.g., pain, instability, stiffness), major trauma or surgery to the lower limbs less than 2 years ago
* Specific vestibular or balance disorders
* Use of medication that could affect balance (e.g., ototoxic or centrally-acting drugs)
* Having a medical diagnosis for, being treated by a rheumatologist for, or taking medication for a rheumatic condition
* (History of) a neurological disorder (e.g., neuropathy)
* Problems with vision that are not corrected by glasses, contact lenses or surgical eye correction
* Recent history of ankle problem (e.g., ankle sprain less than 3 weeks ago)
* Being on absolute/relative bed rest due to pregnancy complications
* (History of) inflammatory (e.g., gout, endometriosis), (auto)immune (e.g., lupus, ankylosis spondylitis, rheumatoid arthritis, psoriasis, Crohn's disease, Graves' disease, Hashimoto's thyroiditis, colitis ulcerosa, multiple sclerosis, etc.), hypothyroidism, or cancer.
* Having (had) a formal diagnosis of a psychiatric disorder (e.g., psychotic disorder).

Where it's running

• Hasselt University
  Hasselt, Belgium Recruiting
• KU Leuven
  Leuven, Belgium Recruiting

Study contacts

• Principal investigator: Lotte Janssens, Prof, PhD, PT — Hasselt University
• Study coordinator: Lotte Janssens, Prof, PhD
• Email: lotte.janssens@uhasselt.be
• Phone: +32 474 43 56 39

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.