Evaluating if pain modulation predicts improvement in chronic low back pain treatment
Is Conditioned Pain Modulation Predictive of Clinical Improvement in Patients With Chronic Low Back Pain?
This study is testing if a person's ability to manage pain can help predict how well they will respond to physical therapy for chronic low back pain.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 57 (estimated) |
| Ages | 18 Years to 64 Years |
| Sex | All |
| Sponsor | Brooke Army Medical Center Federal |
| Locations | 1 site (Fort Sam Houston, Texas) |
| Trial ID | NCT06544525 on ClinicalTrials.gov |
What this trial studies
This study investigates whether conditioned pain modulation (CPM) can predict clinical improvement in patients suffering from chronic low back pain. It focuses on the body's ability to manage pain through its descending pain pathways and examines how physical therapy may enhance this function. Participants will undergo CPM testing to assess their pain modulation capabilities before and after a standard physical therapy regimen. The goal is to determine if improvements in CPM correlate with better outcomes in pain management.
Who should consider this trial
Good fit: Ideal candidates are English-speaking adults aged 18-64 with chronic low back pain lasting more than three months and specific pain severity levels.
Not a fit: Patients with serious spinal pathologies, neurological diseases, or those currently involved in litigation related to low back pain may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective treatment strategies for chronic low back pain by identifying patients who are likely to benefit from physical therapy.
How similar studies have performed: Previous studies have indicated that impaired conditioned pain modulation is common in chronic pain conditions, suggesting that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * DEERS eligible * English speaking * Age 18-64 years * ODI baseline ≥25% * NPRS baseline ≥3/10 * Low back pain symptoms greater than 3 months * Must be able to commit to at least six weeks of physical therapy interventions Exclusion Criteria: * Serious spinal pathology (acute fracture, active cancer, inflammation, inflammatory arthropathy) * Low back pain symptoms radiating below the knee * Pregnancy * Diagnosed neurological disease including traumatic brain injury, multiple sclerosis, chronic regional pain syndrome, and fibromyalgia. * History spinal surgery * Currently under litigation related to low back pain * Currently going through Medical Evaluation Board (MEB) * Retiring or separating from the military within a year
Where this trial is running
Fort Sam Houston, Texas
- Brooke Army Medical Center — Fort Sam Houston, Texas, United States (Recruiting)
Study contacts
- Principal investigator: Kyle Petrey, DPT — Bamc
- Study coordinator: Kyle R Petrey, DPT
- Email: kyle.r.petrey.mil@health.mil
- Phone: 8472742794
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.